Does Thymosin Alpha-1 build up with twice weekly dosing?

Hardly at all in the model. With a half-life of about 2 hours, a twice weekly interval is 5 or more half-lives, so each dose has almost fully cleared before the next one and every dose draws about the same curve. The level is near zero for much of each interval.

Is this chart my actual Thymosin Alpha-1 level?

No. It is a modeled estimate from a published half-life, using the same one-compartment model as the Dose Track app. Real levels vary with body weight, injection site, kidney and liver function and other factors, and only a lab test measures them. It is not medical advice.

Thymosin Alpha-1 Half-Life: Peak and Steady State Chart

Q: When does Thymosin Alpha-1 peak after a dose?

Blood levels peak about 2 hours after an injection under the skin, according to Thymosin alpha-1 (review), 2001. Individual timing varies with the injection site, the amount and the person.

Q: How long does Thymosin Alpha-1 take to reach steady state?

About 10 hours of regular dosing at the same amount and interval, which is 5 half-lives. With a half-life of about 2 hours, levels reach about 50% of steady state after 2 hours and about 90% after 6.6 hours. Changing the dose or interval starts a new climb toward a new steady state.

Q: How long does Thymosin Alpha-1 stay in your system after the last dose?

Roughly 5 half-lives, about 10 hours, until about 97% has cleared in the model. Half is gone about 2 hours after levels start falling. Real clearance varies from person to person, and a drug can still have effects after levels are low.

Short answer: Thymosin Alpha-1 has a half-life of about 2 hours (Thymosin alpha-1 (review), 2001) and reaches steady state after about 10 hours of regular dosing. Levels peak about 2 hours after an injection under the skin. With twice weekly dosing it clears almost completely between doses, so levels do not build up.

What do Thymosin Alpha-1 levels look like with twice weekly dosing?

Relative units: 1 on the scale is one full dose. There is no FDA label dose for this use, so the chart shows the shape of the curve, not an amount. Dashed line: 5 half-lives. Change the amount or schedule in the calculator.

When does Thymosin Alpha-1 peak after a dose?

Levels peak about 2 hours after an injection under the skin.

How long does Thymosin Alpha-1 take to reach steady state?

With regular dosing at a fixed amount and interval, levels climb toward steady state by the same fraction every half-life, whatever the dose. At a half-life of about 2 hours:

Time from the first dose to each share of steady state, Thymosin Alpha-1 (half-life 2 hours).
Share of steady state	Half-lives	Time
50%	1	2 hours
75%	2	4 hours
90%	3.3	6.6 hours
97% (Dose Track's steady-state rule)	5	10 hours

How much do Thymosin Alpha-1 levels swing between doses?

The longer the gap between doses compared with the half-life, the bigger the swing from peak to trough and the less the levels build up. These ratios do not depend on the amount.

Steady-state peak:trough and build-up by dosing interval, Thymosin Alpha-1, in Dose Track's model.
Interval	Peak : trough	Build-up vs one dose
Daily	over 1,000 : 1	1×
Every other day	over 1,000 : 1	1×
Twice weekly	over 1,000 : 1	1×
Weekly	over 1,000 : 1	1×
Every 2 weeks	over 1,000 : 1	1×

Build-up is the accumulation ratio 1 / (1 − e^−k·τ), with k = ln 2 / half-life and τ the interval.

How long does Thymosin Alpha-1 stay in your system?

After the last dose, about half is gone every 2 hours. After 5 half-lives, about 10 hours, roughly 97% has cleared in the model.

Where do these numbers come from?

A 2001 review in the American Journal of Health-System Pharmacy reports peak serum levels within about 2 hours and a serum half-life of about 2 hours.

Thymosin alpha-1 (review). Am J Health Syst Pharm. 2001.

The curve uses the half-life, time to peak, route and bioavailability built into the Dose Track app for Thymosin Alpha-1, and the same one-compartment model with first-order absorption. These are modeled estimates from published half-lives, drawn with the same one-compartment model as the Dose Track app. Real levels vary from person to person, and only a lab test measures them. This is not medical advice and not a dosing recommendation; dosing decisions belong with you and your prescriber.

Vial sizes and syringe math are in the Thymosin Alpha-1 guide.

When does Thymosin Alpha-1 peak and reach steady state?