Does ipamorelin build up with daily dosing?

Hardly at all in the model. With a half-life of about 2 hours, a daily interval is 5 or more half-lives, so each dose has almost fully cleared before the next one and every dose draws about the same curve. The level is near zero for much of each interval.

Is this chart my actual ipamorelin level?

No. It is a modeled estimate from a published half-life, using the same one-compartment model as the Dose Track app. Real levels vary with body weight, injection site, kidney and liver function and other factors, and only a lab test measures them. It is not medical advice.

Ipamorelin Half-Life: Peak and Steady State Chart

Q: How long does ipamorelin take to reach steady state?

About 10 hours of regular dosing at the same amount and interval, which is 5 half-lives. With a half-life of about 2 hours, levels reach about 50% of steady state after 2 hours and about 90% after 6.6 hours. Changing the dose or interval starts a new climb toward a new steady state.

Q: How long does ipamorelin stay in your system after the last dose?

Roughly 5 half-lives, about 10 hours, until about 97% has cleared in the model. Half is gone about 2 hours after levels start falling. Real clearance varies from person to person, and a drug can still have effects after levels are low.

Short answer: Ipamorelin has a half-life of about 2 hours (Gobburu JV, et al. 1999) and reaches steady state after about 10 hours of regular dosing. We could not confirm a published time to peak for ipamorelin, so we do not state one. With daily dosing it clears almost completely between doses, so levels do not build up.

What do ipamorelin levels look like with daily dosing?

Relative units: 1 on the scale is one full dose. There is no FDA label dose for this use, so the chart shows the shape of the curve, not an amount. Dashed line: 5 half-lives. Change the amount or schedule in the calculator.

When does ipamorelin peak after a dose?

We could not confirm a published time to peak for ipamorelin, so we do not state one. The curve still needs a rise time, so it uses the app's modeling estimate; treat the shape of the first day or two as approximate.

How long does ipamorelin take to reach steady state?

With regular dosing at a fixed amount and interval, levels climb toward steady state by the same fraction every half-life, whatever the dose. At a half-life of about 2 hours:

Time from the first dose to each share of steady state, ipamorelin (half-life 2 hours).
Share of steady state	Half-lives	Time
50%	1	2 hours
75%	2	4 hours
90%	3.3	6.6 hours
97% (Dose Track's steady-state rule)	5	10 hours

How much do ipamorelin levels swing between doses?

The longer the gap between doses compared with the half-life, the bigger the swing from peak to trough and the less the levels build up. These ratios do not depend on the amount.

Steady-state peak:trough and build-up by dosing interval, ipamorelin, in Dose Track's model.
Interval	Peak : trough	Build-up vs one dose
Daily	over 1,000 : 1	1×
Every other day	over 1,000 : 1	1×
Twice weekly	over 1,000 : 1	1×
Weekly	over 1,000 : 1	1×
Every 2 weeks	over 1,000 : 1	1×

Build-up is the accumulation ratio 1 / (1 − e^−k·τ), with k = ln 2 / half-life and τ the interval.

How long does ipamorelin stay in your system?

After the last dose, about half is gone every 2 hours. After 5 half-lives, about 10 hours, roughly 97% has cleared in the model.

Where do these numbers come from?

A human study (Gobburu 1999) found a terminal half-life of about 2 hours. That study gave ipamorelin into a vein, so it reports no time to peak for an injection under the skin, and we leave that out.

Gobburu JV, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers. Pharm Res. 1999.

The curve uses the half-life, time to peak, route and bioavailability built into the Dose Track app for ipamorelin, and the same one-compartment model with first-order absorption. These are modeled estimates from published half-lives, drawn with the same one-compartment model as the Dose Track app. Real levels vary from person to person, and only a lab test measures them. This is not medical advice and not a dosing recommendation; dosing decisions belong with you and your prescriber.

Vial sizes and syringe math are in the Ipamorelin guide.

When does ipamorelin peak and reach steady state?