Does tesamorelin build up with daily dosing?

Hardly at all in the model. With a half-life of about 8 minutes, a daily interval is 5 or more half-lives, so each dose has almost fully cleared before the next one and every dose draws about the same curve. The level is near zero for much of each interval.

Is this chart my actual tesamorelin level?

No. It is a modeled estimate from a published half-life, using the same one-compartment model as the Dose Track app. Real levels vary with body weight, injection site, kidney and liver function and other factors, and only a lab test measures them. It is not medical advice.

Tesamorelin Half-Life: Peak and Steady State Chart

Q: When does tesamorelin peak after a dose?

Blood levels peak about 9 minutes after an injection under the skin, according to Egrifta SV (tesamorelin) label. Individual timing varies with the injection site, the amount and the person.

Q: How long does tesamorelin take to reach steady state?

About 39 minutes of regular dosing at the same amount and interval, which is 5 half-lives. With a half-life of about 8 minutes, levels reach about 50% of steady state after 8 minutes and about 90% after 26 minutes. Changing the dose or interval starts a new climb toward a new steady state.

Q: How long does tesamorelin stay in your system after the last dose?

Roughly 5 half-lives, about 39 minutes, until about 97% has cleared in the model. Half is gone about 8 minutes after levels start falling. Real clearance varies from person to person, and a drug can still have effects after levels are low.

Short answer: Tesamorelin has a half-life of about 8 minutes (Egrifta SV (tesamorelin) label) and reaches steady state after about 39 minutes of regular dosing. Levels peak about 9 minutes after an injection under the skin. With daily dosing it clears almost completely between doses, so levels do not build up.

What do tesamorelin levels look like with daily dosing?

The Egrifta SV label dose is 1.4 mg once daily, injected under the skin. Source: Egrifta SV (tesamorelin) label. Bioavailability 4% as in the app. Dashed line: 5 half-lives. Change the amount or schedule in the calculator.

When does tesamorelin peak after a dose?

Levels peak about 9 minutes after an injection under the skin.

How long does tesamorelin take to reach steady state?

With regular dosing at a fixed amount and interval, levels climb toward steady state by the same fraction every half-life, whatever the dose. At a half-life of about 8 minutes:

Time from the first dose to each share of steady state, tesamorelin (half-life 8 minutes).
Share of steady state	Half-lives	Time
50%	1	8 minutes
75%	2	16 minutes
90%	3.3	26 minutes
97% (Dose Track's steady-state rule)	5	39 minutes

How much do tesamorelin levels swing between doses?

The longer the gap between doses compared with the half-life, the bigger the swing from peak to trough and the less the levels build up. These ratios do not depend on the amount.

Steady-state peak:trough and build-up by dosing interval, tesamorelin, in Dose Track's model.
Interval	Peak : trough	Build-up vs one dose
Daily	over 1,000 : 1	1×
Every other day	over 1,000 : 1	1×
Twice weekly	over 1,000 : 1	1×
Weekly	over 1,000 : 1	1×
Every 2 weeks	over 1,000 : 1	1×

Build-up is the accumulation ratio 1 / (1 − e^−k·τ), with k = ln 2 / half-life and τ the interval.

How long does tesamorelin stay in your system?

After the last dose, about half is gone every 8 minutes. After 5 half-lives, about 39 minutes, roughly 97% has cleared in the model.

Where do these numbers come from?

The current FDA Egrifta SV label reports a mean half-life of 8 minutes after a single injection under the skin, and a median time to peak of 0.15 hours (about 9 minutes). The Egrifta WR label reports 11 minutes and the same 0.15-hour peak. An older 1 mg Egrifta label reported 26 to 38 minutes, measured after 14 days of daily dosing.

The curve uses the half-life, time to peak, route and bioavailability built into the Dose Track app for tesamorelin, and the same one-compartment model with first-order absorption. These are modeled estimates from published half-lives, drawn with the same one-compartment model as the Dose Track app. Real levels vary from person to person, and only a lab test measures them. This is not medical advice and not a dosing recommendation; dosing decisions belong with you and your prescriber.

Vial sizes and syringe math are in the Tesamorelin guide.

When does tesamorelin peak and reach steady state?