What is the difference between Ozempic and Wegovy?

Both contain semaglutide, made by Novo Nordisk. Ozempic is labeled for type 2 diabetes (with cardiovascular and kidney risk reduction), with a maximum label dose of 2 mg once weekly. Wegovy is labeled for weight reduction, cardiovascular risk reduction and MASH, with its own pens and a schedule that reaches 2.4 mg, and up to 7.2 mg once weekly for some adults per its label.

What is the difference between Mounjaro and Zepbound?

Both are tirzepatide from Eli Lilly with the same 2.5 mg starting dose and 15 mg once-weekly maximum in their labels. Mounjaro is labeled for type 2 diabetes; Zepbound is labeled for weight reduction and for obstructive sleep apnea in adults with obesity.

Is there a GLP-1 pill?

Yes. The FDA-approved oral options covered here are Rybelsus and Ozempic tablets (semaglutide, type 2 diabetes), the Wegovy pill (semaglutide, weight reduction and cardiovascular risk reduction) and Foundayo (orforglipron, weight reduction). All are taken once daily.

Which GLP-1 medications are taken once a week?

Ozempic, Wegovy, Mounjaro, Zepbound and Trulicity are once-weekly injections. Saxenda is a once-daily injection, and the tablets (Ozempic tablets, Rybelsus, Wegovy pill, Foundayo) are once daily.

Why do GLP-1 labels start at a low dose?

Each label sets a starting dose and steps it up over weeks or months. Several labels describe the starting dose as an initiation dose rather than a maintenance dose; for example, the Rybelsus label says the 3 mg starting dose is not effective for glycemic control, and the Ozempic label ties its escalation to reducing gastrointestinal adverse reactions. The exact wording for each brand is on its page.

Is tirzepatide a GLP-1?

The Mounjaro and Zepbound labels describe tirzepatide as a GIP and GLP-1 receptor agonist, so it acts on two receptors rather than GLP-1 alone.

GLP-1 Dose Schedules: Ozempic, Wegovy, Mounjaro, Zepbound

Q: Is orforglipron FDA-approved?

Yes. The FDA approved orforglipron as Foundayo (Eli Lilly) on April 1, 2026, as a once-daily tablet for weight reduction. Its label schedule starts at 0.8 mg once daily, with a maximum of 17.2 mg once daily.

Short answer: The brands covered here are Ozempic (injection and tablets), Rybelsus, Wegovy (injection and pill), Mounjaro, Zepbound, Saxenda, Trulicity and Foundayo. Every label starts at a low dose and steps up: the weekly injections every 4 weeks, the daily tablets every 30 days, Saxenda every week. Each brand page has the full label schedule with section numbers.

Which GLP-1 brands are FDA-approved, and how are they dosed?

Starting and highest doses below are from each product's current FDA label. Every brand page has the full week-by-week schedule with label section numbers. This is reference information, not personalized advice.

Starting and maximum label doses by brand. Reviewed October 17, 2026.
Brand	Generic	Maker	Form	Label starting dose	Label maximum dose	Approved for
Ozempic	semaglutide	Novo Nordisk	Once weekly injection	0.25 mg once weekly	2 mg once weekly	Type 2 diabetes; cardiovascular and kidney risk reduction in type 2 diabetes
Ozempic pill	semaglutide	Novo Nordisk	Once daily tablet	1.5 mg once daily	9 mg once daily	Type 2 diabetes
Rybelsus	semaglutide	Novo Nordisk	Once daily tablet	3 mg once daily	14 mg once daily	Type 2 diabetes
Wegovy	semaglutide	Novo Nordisk	Once weekly injection	0.25 mg once weekly	7.2 mg once weekly	Weight reduction; cardiovascular risk reduction; MASH (accelerated approval)
Wegovy pill	semaglutide	Novo Nordisk	Once daily tablet	1.5 mg once daily	25 mg once daily	Weight reduction; cardiovascular risk reduction
Mounjaro	tirzepatide	Eli Lilly and Company	Once weekly injection	2.5 mg once weekly	15 mg once weekly	Type 2 diabetes
Zepbound	tirzepatide	Eli Lilly and Company	Once weekly injection	2.5 mg once weekly	15 mg once weekly	Weight reduction; obstructive sleep apnea with obesity
Saxenda	liraglutide	Novo Nordisk	Once daily injection	0.6 mg once daily	3 mg once daily	Weight reduction
Trulicity	dulaglutide	Eli Lilly and Company	Once weekly injection	0.75 mg once weekly	4.5 mg once weekly	Type 2 diabetes; cardiovascular risk reduction
Foundayo	orforglipron	Eli Lilly and Company	Once daily tablet	0.8 mg once daily	17.2 mg once daily	Weight reduction

Which brands are the same medicine?

Several brands share one active ingredient but carry different labels, indications and dose steps. Semaglutide is sold as Ozempic (weekly injection), Ozempic tablets, Rybelsus (daily tablet), Wegovy (weekly injection) and the Wegovy pill. Tirzepatide, which the labels describe as a GIP and GLP-1 receptor agonist, is sold as Mounjaro and Zepbound. Saxenda is liraglutide, Trulicity is dulaglutide and Foundayo is orforglipron.

Milligram doses are not comparable across forms: the semaglutide tablets use much larger numbers than the injections because the labels set them separately. Compare schedules within a brand, not across brands.

Which GLP-1s are weekly and which are daily?

Once weekly by injection: Ozempic, Wegovy, Mounjaro, Zepbound and Trulicity. Once daily by injection: Saxenda. Once daily by mouth: Ozempic tablets, Rybelsus, the Wegovy pill and Foundayo.

The semaglutide tablets have strict label instructions about taking them on an empty stomach with a small amount of water; Foundayo's label does not. The details, with section numbers, are on each tablet's page.

Is orforglipron FDA-approved?

Yes. Orforglipron was approved on April 1, 2026 under the brand name Foundayo (Eli Lilly), as a once-daily tablet for weight reduction. Its label schedule, tablet strengths and side effect rates are on the Foundayo page.

More GLP-1 guides

Missed a dose? What each label says, for Ozempic, Wegovy, Mounjaro and Zepbound.
Storage, including pens left out of the fridge.
Semaglutide vs tirzepatide, and what switching looks like.
Compounded GLP-1 vial units: converting mg to syringe units.
Half-life calculator and how long semaglutide, tirzepatide and liraglutide and dulaglutide stay in your system.
GLP-1 microdosing: what the evidence says.
Dose Track vs Shotsy for GLP-1 tracking.

GLP-1 medications: dose schedules, titration and side effects by brand