How much does ligandrol build up with daily dosing?

At steady state on a daily schedule, the model's level is about 2.35 times what one dose gives, and it swings about 1.62:1 between the peak and the trough before the next dose. Longer gaps between doses mean less build-up and a bigger swing.

Is this chart my actual ligandrol level?

No. It is a modeled estimate from a published half-life, using the same one-compartment model as the Dose Track app. Real levels vary with body weight, food, kidney and liver function and other factors, and only a lab test measures them. It is not medical advice.

Ligandrol Half-Life: Peak and Steady State Chart

Q: How long does ligandrol take to reach steady state?

About 6.3 days of regular dosing at the same amount and interval, which is 5 half-lives. With a half-life of about 30 hours, levels reach about 50% of steady state after 30 hours and about 90% after 4.2 days. Changing the dose or interval starts a new climb toward a new steady state.

Q: How long does ligandrol stay in your system after the last dose?

Roughly 5 half-lives, about 6.3 days, until about 97% has cleared in the model. Half is gone about 30 hours after levels start falling. Real clearance varies from person to person, and a drug can still have effects after levels are low.

Short answer: Ligandrol has a half-life of about 30 hours (Basaria S et al. 2013) and reaches steady state after about 6.3 days of regular dosing. We could not confirm a published time to peak for ligandrol, so we do not state one. On a daily schedule the model builds up to about 2.3× a single dose, with a peak-to-trough swing of about 1.62:1.

What do ligandrol levels look like with daily dosing?

Relative units: 1 on the scale is one full dose. There is no FDA label dose for this use, so the chart shows the shape of the curve, not an amount. Dashed line: 5 half-lives. Change the amount or schedule in the calculator.

When does ligandrol peak after a dose?

We could not confirm a published time to peak for ligandrol, so we do not state one. The curve still needs a rise time, so it uses the app's modeling estimate; treat the shape of the first day or two as approximate.

How long does ligandrol take to reach steady state?

With regular dosing at a fixed amount and interval, levels climb toward steady state by the same fraction every half-life, whatever the dose. At a half-life of about 30 hours:

Time from the first dose to each share of steady state, ligandrol (half-life 30 hours).
Share of steady state	Half-lives	Time
50%	1	30 hours
75%	2	2.5 days
90%	3.3	4.2 days
97% (Dose Track's steady-state rule)	5	6.3 days

How much do ligandrol levels swing between doses?

The longer the gap between doses compared with the half-life, the bigger the swing from peak to trough and the less the levels build up. These ratios do not depend on the amount.

Steady-state peak:trough and build-up by dosing interval, ligandrol, in Dose Track's model.
Interval	Peak : trough	Build-up vs one dose
Daily	1.62 : 1	2.35×
Every other day	2.8 : 1	1.49×
Twice weekly	6.41 : 1	1.17×
Weekly	44.5 : 1	1.02×
Every 2 weeks	over 1,000 : 1	1×

Build-up is the accumulation ratio 1 / (1 − e^−k·τ), with k = ln 2 / half-life and τ the interval.

How long does ligandrol stay in your system?

After the last dose, about half is gone every 30 hours. After 5 half-lives, about 6.3 days, roughly 97% has cleared in the model.

Where do these numbers come from?

In the phase 1 trial in healthy young men (Basaria 2013), LGD-4033 had a long elimination half-life of 24 to 36 hours, and blood levels on day 21 were nearly three times those on day 1. Dose Track uses 30 hours. The paper gives no single time to peak, so we do not list one.

Basaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95.

The curve uses the half-life, time to peak, route and bioavailability built into the Dose Track app for ligandrol, and the same one-compartment model with first-order absorption. These are modeled estimates from published half-lives, drawn with the same one-compartment model as the Dose Track app. Real levels vary from person to person, and only a lab test measures them. This is not medical advice and not a dosing recommendation; dosing decisions belong with you and your prescriber.

Vial sizes and syringe math are in the Ligandrol (LGD-4033) guide.

When does ligandrol peak and reach steady state?