Does splitting CJC-1295 with DAC into more frequent doses keep levels steadier?

In the model, it narrows the swing but not the average. With the same total per week, the peak-to-trough ratio at steady state is about 1.25:1 twice weekly, about 1.67:1 weekly. Which schedule to use is a decision for you and your prescriber.

Is this chart my actual CJC-1295 with DAC level?

No. It is a modeled estimate from a published half-life, using the same one-compartment model as the Dose Track app. Real levels vary with body weight, injection site, kidney and liver function and other factors, and only a lab test measures them. It is not medical advice.

CJC-1295 with DAC Half-Life: Peak and Steady State Chart

Q: How long does CJC-1295 with DAC take to reach steady state?

About 40 days (~5.7 weeks) of regular dosing at the same amount and interval, which is 5 half-lives. With a half-life of about 8 days, levels reach about 50% of steady state after 8 days and about 90% after 27 days (~3.8 weeks). Changing the dose or interval starts a new climb toward a new steady state.

Q: How long does CJC-1295 with DAC stay in your system after the last dose?

Roughly 5 half-lives, about 40 days (~5.7 weeks), until about 97% has cleared in the model. Half is gone about 8 days after levels start falling. Real clearance varies from person to person, and a drug can still have effects after levels are low.

Short answer: CJC-1295 with DAC has a half-life of about 8 days (Teichman SL, et al. 2006) and reaches steady state after about 40 days (~5.7 weeks) of regular dosing. We could not confirm a published time to peak for CJC-1295 with DAC, so we do not state one. With the same total per week, Dose Track's model gives a peak-to-trough swing of about 1.25:1 twice weekly and about 1.67:1 weekly.

Weekly vs twice weekly: how do CJC-1295 with DAC levels compare?

Relative units: 1 on the scale is one full dose. There is no FDA label dose for this use, so the chart shows the shape of the curve, not an amount. Dashed line: 5 half-lives. Change the amount or schedule in the calculator.

When does CJC-1295 with DAC peak after a dose?

We could not confirm a published time to peak for CJC-1295 with DAC, so we do not state one. The curve still needs a rise time, so it uses the app's modeling estimate; treat the shape of the first day or two as approximate.

How long does CJC-1295 with DAC take to reach steady state?

With regular dosing at a fixed amount and interval, levels climb toward steady state by the same fraction every half-life, whatever the dose. At a half-life of about 8 days:

Time from the first dose to each share of steady state, CJC-1295 with DAC (half-life 8 days).
Share of steady state	Half-lives	Time
50%	1	8 days
75%	2	16 days
90%	3.3	27 days (~3.8 weeks)
97% (Dose Track's steady-state rule)	5	40 days (~5.7 weeks)

How much do CJC-1295 with DAC levels swing between doses?

The longer the gap between doses compared with the half-life, the bigger the swing from peak to trough and the less the levels build up. These ratios do not depend on the amount.

Steady-state peak:trough and build-up by dosing interval, CJC-1295 with DAC, in Dose Track's model.
Interval	Peak : trough	Build-up vs one dose
Daily	1.04 : 1	12.05×
Every other day	1.11 : 1	6.29×
Twice weekly	1.25 : 1	3.82×
Weekly	1.67 : 1	2.2×
Every 2 weeks	3.04 : 1	1.42×

Build-up is the accumulation ratio 1 / (1 − e^−k·τ), with k = ln 2 / half-life and τ the interval.

How long does CJC-1295 with DAC stay in your system?

After the last dose, about half is gone every 8 days. After 5 half-lives, about 40 days (~5.7 weeks), roughly 97% has cleared in the model.

Where do these numbers come from?

A study in healthy adults (Teichman 2006) estimated a half-life of 5.8 to 8.1 days. We could not confirm a time to peak, so we leave it out.

Teichman SL, et al. Prolonged stimulation of GH and IGF-I secretion by CJC-1295 in healthy adults. J Clin Endocrinol Metab. 2006.

The curve uses the half-life, time to peak, route and bioavailability built into the Dose Track app for CJC-1295 with DAC, and the same one-compartment model with first-order absorption. These are modeled estimates from published half-lives, drawn with the same one-compartment model as the Dose Track app. Real levels vary from person to person, and only a lab test measures them. This is not medical advice and not a dosing recommendation; dosing decisions belong with you and your prescriber.

Vial sizes and syringe math are in the CJC-1295 with DAC guide.

When does CJC-1295 with DAC peak and reach steady state?