How much does Vitamin K2 build up with daily dosing?

At steady state on a daily schedule, the model's level is about 4.85 times what one dose gives, and it swings about 1.2:1 between the peak and the trough before the next dose. Longer gaps between doses mean less build-up and a bigger swing.

Is this chart my actual Vitamin K2 level?

No. It is a modeled estimate from a published half-life, using the same one-compartment model as the Dose Track app. Real levels vary with body weight, food, kidney and liver function and other factors, and only a lab test measures them. It is not medical advice.

Vitamin K2 Half-Life: Peak and Steady State Chart

Q: When does Vitamin K2 peak after a dose?

Blood levels peak about 6 hours after a dose by mouth, according to Sato T et al. 2012. Individual timing varies with food, the amount and the person.

Q: How long does Vitamin K2 take to reach steady state?

About 15 days of regular dosing at the same amount and interval, which is 5 half-lives. With a half-life of about 3 days, levels reach about 50% of steady state after 3 days and about 90% after 10 days. Changing the dose or interval starts a new climb toward a new steady state.

Q: How long does Vitamin K2 stay in your system after the last dose?

Roughly 5 half-lives, about 15 days, until about 97% has cleared in the model. Half is gone about 3 days after levels start falling. Real clearance varies from person to person, and a drug can still have effects after levels are low.

Short answer: Vitamin K2 has a half-life of about 3 days (Schurgers LJ et al. 2007) and reaches steady state after about 15 days of regular dosing. Levels peak about 6 hours after a dose by mouth. On a daily schedule the model builds up to about 4.8× a single dose, with a peak-to-trough swing of about 1.2:1.

What do Vitamin K2 levels look like with daily dosing?

Relative units: 1 on the scale is one full dose. There is no FDA label dose for this use, so the chart shows the shape of the curve, not an amount. Dashed line: 5 half-lives. Change the amount or schedule in the calculator.

When does Vitamin K2 peak after a dose?

Levels peak about 6 hours after a dose by mouth.

How long does Vitamin K2 take to reach steady state?

With regular dosing at a fixed amount and interval, levels climb toward steady state by the same fraction every half-life, whatever the dose. At a half-life of about 3 days:

Time from the first dose to each share of steady state, Vitamin K2 (half-life 3 days).
Share of steady state	Half-lives	Time
50%	1	3 days
75%	2	6 days
90%	3.3	10 days
97% (Dose Track's steady-state rule)	5	15 days

How much do Vitamin K2 levels swing between doses?

The longer the gap between doses compared with the half-life, the bigger the swing from peak to trough and the less the levels build up. These ratios do not depend on the amount.

Steady-state peak:trough and build-up by dosing interval, Vitamin K2, in Dose Track's model.
Interval	Peak : trough	Build-up vs one dose
Daily	1.2 : 1	4.85×
Every other day	1.5 : 1	2.7×
Twice weekly	2.11 : 1	1.8×
Weekly	4.71 : 1	1.25×
Every 2 weeks	23.7 : 1	1.04×

Build-up is the accumulation ratio 1 / (1 − e^−k·τ), with k = ln 2 / half-life and τ the interval.

How long does Vitamin K2 stay in your system?

After the last dose, about half is gone every 3 days. After 5 half-lives, about 15 days, roughly 97% has cleared in the model.

Where do these numbers come from?

In a study comparing vitamin K1 with MK-7 (Schurgers 2007), both peaked about 4 hours after a dose, and MK-7 had a very long half-life, building up 7- to 8-fold with daily intake. Later studies found MK-7 peaked about 6 hours after a dose (Sato 2012) and reviews give a half-life of about 68 to 72 hours (Akbulut 2020). Dose Track uses 72 hours and 6 hours.

The curve uses the half-life, time to peak, route and bioavailability built into the Dose Track app for Vitamin K2, and the same one-compartment model with first-order absorption. These are modeled estimates from published half-lives, drawn with the same one-compartment model as the Dose Track app. Real levels vary from person to person, and only a lab test measures them. This is not medical advice and not a dosing recommendation; dosing decisions belong with you and your prescriber.

Vial sizes and syringe math are in the Vitamin K2 (MK-7) guide.

When does Vitamin K2 peak and reach steady state?