Short answer: Compounded semaglutide and tirzepatide are not FDA-approved, so no FDA label sets their storage. FDA says to use multi-dose vials within 28 days of first use and to throw them away after that, even if the compounder says longer. FDA also says not to use an injectable GLP-1 that arrives warm or without enough cold packs. Follow the pharmacy label for temperature.
No. The storage figures on the Ozempic, Wegovy, Mounjaro and Zepbound pages come from stability testing of those exact products. They do not transfer to a compounded vial, which has a different formula, container and often added ingredients. The compounding pharmacy sets a beyond-use date on its own label.
What does exist is FDA guidance aimed at compounded GLP-1 users, and the general CDC rule for multi-dose vials.
From FDA's page on unapproved GLP-1 drugs: “Generally, FDA recommends that vials containing multiple doses of sterile medications be used within 28 days after the first use because there is an increased risk of contamination after 28 days.”
CDC, citing USP chapter 797, gives the same 28-day rule for opened multi-dose vials unless the manufacturer states otherwise, and never past the original expiration date.
Vial math: semaglutide and tirzepatide. The 28 days is a contamination limit set by FDA, not a stability result for any one compounded formula. Not personalized advice.