Short answer: Store Zepbound in the fridge at 36-46°F (2-8°C) in its carton. Single-dose pens and vials may be kept unrefrigerated, not above 86°F (30°C), for up to a total of 21 days. A KwikPen or multi-dose vial is thrown away after 30 days at room temperature, 30 days after first use, or 4 weekly doses. Do not use Zepbound that has frozen.
| Form | Storage | Limit |
|---|---|---|
| Single-dose pen | Refrigerator 36-46°F (2-8°C); if needed, not above 86°F (30°C) | Discard after a total of 21 days at room temperature |
| Single-dose vial (cartons of 1 or 4) | Same as the pen | Total of 21 days at room temperature; throw away opened vials after use |
| Multi-dose vial or KwikPen, unopened | Refrigerator until the expiration date | If kept at room temperature (up to 86°F), throw away after 30 days |
| Multi-dose vial or KwikPen, in use | Refrigerator or up to 86°F (30°C), in the carton | 30 days at room temperature, 30 days after first use, or 4 weekly doses |
Section 16.2 applies to all forms: “Do not freeze ZEPBOUND. Do not use ZEPBOUND if frozen. Protect ZEPBOUND from heat and light. Store ZEPBOUND in the original carton to protect from light.”
Zepbound comes in single-dose vials as well as pens. Per the single-dose vial Instructions for Use, store unopened vials in the fridge; “You may store the unopened vial at room temperature up to 86°F (30°C) for up to a total of 21 days,” and “Throw away all opened vials after use, even if there is medicine left in the vial.”
If you buy the 4-vial carton, each vial has its own 21-day total. Keep them in the carton to protect them from light.
The multi-dose vial Instructions for Use: once opened, store it in the fridge or at room temperature up to 86°F, and throw it away after a total of 30 days at room temperature, 30 days after first use, or 4 weekly doses, “even if there is medicine left in it.” See the Zepbound guide and the tirzepatide page.
Frozen: “Do not freeze your pen. If the pen has been frozen, throw the pen away and use a new pen” (pen Instructions for Use). The same applies to vials.
Too warm: the room-temperature allowance stops at 86°F (30°C). Above that the label gives no allowance; ask your pharmacist. Do not use Zepbound that is cloudy, discolored or has particles.
Single-dose pens and vials can travel unrefrigerated, not above 86°F (30°C), within their 21-day total. In a hot car or a sunny window the temperature can pass 86°F quickly, so use an insulated bag.
More in the travel guide.