Short answer: Pregnyl is injected into a muscle only. The label lists regimens advocated by various authorities: four options for undescended testicles in boys aged 4 to 9, such as 4000 USP units 3 times weekly for 3 weeks; two for male hypogonadotropic hypogonadism; and 5000 to 10,000 USP units 1 day after the last gonadotropin dose to trigger ovulation.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Pregnyl is approved for: Pregnyl (hCG) is approved for prepubertal cryptorchidism (undescended testicles) not caused by a physical blockage, for selected cases of hypogonadotropic hypogonadism in males (low testosterone from a pituitary deficiency), and to induce ovulation and pregnancy in anovulatory, infertile women whose anovulation is not from primary ovarian failure and who have been treated with human gonadotropins. The label states hCG has not been shown to be effective for treating obesity (Indications and Usage).
Source
PREGNYL (chorionic gonadotropin) for injection, prescribing information. Organon. DailyMed, version published December 4, 2025. DailyMed setid 1e94155f-19be-4944-b197-be4edbb4faf9
Pregnyl is for intramuscular use only, and each multiple-dose vial is for one patient (Dosage and Administration).
The label says the regimen depends on the use, the patient's age and weight, and the physician's preference, and that the listed regimens "have been advocated by various authorities."
For ovulation induction, Pregnyl is given after treatment with gonadotropins, and the timing is based on monitoring that shows enough follicle growth (Precautions, Laboratory Tests).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Use | Regimen on the label |
|---|---|
| Prepubertal cryptorchidism not due to anatomical obstruction | 4000 USP units 3 times weekly for 3 weeks |
| Prepubertal cryptorchidism not due to anatomical obstruction | 5000 USP units every second day for 4 injections |
| Prepubertal cryptorchidism not due to anatomical obstruction | 15 injections for 500 to 1000 USP units over a period of 6 weeks |
| Prepubertal cryptorchidism not due to anatomical obstruction | 500 USP units 3 times weekly for 4 to 6 weeks; if not successful, another series is begun 1 month later, giving 1000 USP units per injection |
| Selected cases of hypogonadotropic hypogonadism in males | 500 to 1000 USP units 3 times a week for 3 weeks, followed by the same dose twice a week for 3 weeks |
| Selected cases of hypogonadotropic hypogonadism in males | 4000 USP units 3 times weekly for 6 to 9 months, after which the dosage may be reduced to 2000 USP units 3 times weekly for an additional 3 months |
| Induction of ovulation and pregnancy (after gonadotropins) | 5000 to 10,000 USP units 1 day following the last dose of gonadotropins |
For cryptorchidism, the label says therapy is generally started in children between the ages of 4 and 9.
For ovulation induction, the label notes that a dosage of 10,000 USP units is recommended in the labeling for gonadotropins.
Without a natural LH surge, hCG is given when monitoring shows enough follicle development, using pelvic ultrasound alone or with serum estradiol. Ultrasound confirms the number of growing follicles, since estrogen levels do not show their size or number.
If there are signs that OHSS may be developing before hCG is due, the label says to withhold hCG. Sticking to the recommended dose and regimen with careful monitoring is described as important to reduce OHSS risk.
If serious OHSS occurs, gonadotropins including hCG are stopped.
Pregnyl is not indicated in pregnancy. It may be used for luteal phase support but is stopped once pregnancy is confirmed.
In boys treated for cryptorchidism, therapy is stopped if signs of precocious puberty occur.
The solution is inspected for particles and discoloration before use and is not used if either is present.
The Pregnyl label gives no missed-dose instruction. Ask your prescriber what to do if an injection is late, especially for a timed ovulation trigger.
In Dose Track you set up Pregnyl as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.