Short answer: The Clomid label starts with 50 mg (one tablet) daily for 5 days, on or about day 5 of the cycle. Without ovulation, the next course is 100 mg daily for 5 days, as early as 30 days later. Going above 100 mg a day or beyond 5 days is not recommended. Treatment ends after three courses without ovulation, and total use is limited to about six cycles.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Clomid is approved for: Clomid is approved to treat ovulatory dysfunction (not ovulating normally) in women who want to become pregnant, after other causes of infertility are ruled out or treated. The label says there are no adequate studies showing it works for male infertility, and it is not recommended for IVF or combined ovulation-induction regimens (Indications and Usage).
Source
Clomid (clomiPHENE citrate) Tablets, USP, prescribing information. Cosette Pharmaceuticals. DailyMed, version published February 3, 2025. DailyMed setid 2ca373c1-4dba-4126-8616-5c533d606fe5
Clomid is a tablet taken by mouth once a day for a 5-day course. The 100 mg course is two 50 mg tablets taken as a single daily dose (Dosage and Administration).
If bleeding is induced with a progestin or happens on its own, the course starts on or about day 5 of the cycle. With no recent uterine bleeding, it may be started at any time.
Ovulation most often occurs 5 to 10 days after a course, and the label says intercourse should be timed to the expected ovulation.
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Course | Daily dose | Length | When it starts |
|---|---|---|---|
| First course | 50 mg (1 tablet) | 5 days | On or about the 5th day of the cycle, or any time if there has been no recent uterine bleeding |
| Second course (only if no ovulation after the first) | 100 mg (two 50 mg tablets as a single daily dose) | 5 days | As early as 30 days after the previous course, after pregnancy is excluded |
| After three courses without ovulation | Further treatment not recommended | - | The patient is reevaluated |
| Label maximum | 100 mg/day | 5 days | Higher dose or longer course not recommended |
The dose is raised only in women who do not ovulate on 50 mg. If ovulation occurs at 50 mg, there is no advantage to raising the dose in later cycles.
Increasing the dose or length beyond 100 mg a day for 5 days is not recommended.
If three ovulatory responses occur without pregnancy, further treatment is not recommended. If no period follows an ovulatory response, the patient is reevaluated.
Long-term cyclic therapy is not recommended beyond a total of about six cycles (including three ovulatory cycles, per Indications and Usage).
A lower dose or shorter course is particularly recommended when unusual sensitivity is suspected, such as in polycystic ovary syndrome.
Pregnancy, ovarian enlargement and ovarian cysts are ruled out between each treatment cycle, and a pelvic exam is done before each course (Precautions).
If the ovaries enlarge, no more Clomid is given until they return to pretreatment size, and the dose or length of the next course is reduced.
Triglyceride screening is recommended before starting, with periodic checks in women with a personal or family history of high blood fats.
The Clomid label gives no missed-dose instruction. Ask your prescriber what to do if a tablet in a 5-day course is missed.
In Dose Track you set up Clomid as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.