Short answer: For replacement in males with hypogonadism, the Depo-Testosterone label gives 50 to 400 mg every two to four weeks, injected deep into the gluteal muscle. It says the dose depends on age, sex and diagnosis and is adjusted by response and side effects. Before starting, low testosterone is confirmed by morning blood tests on at least two separate days.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Depo-Testosterone is approved for: Depo-Testosterone is approved as testosterone replacement in males with symptoms from low or absent natural testosterone due to primary hypogonadism (testicular failure) or hypogonadotropic hypogonadism (a pituitary or hypothalamus cause). The label says safety and effectiveness in men with age-related ("late-onset") hypogonadism have not been established (Indications and Usage).
Source
DEPO-Testosterone (testosterone cypionate) injection, prescribing information. Pfizer (Pharmacia & Upjohn). DailyMed, version published August 20, 2026. DailyMed setid cfbb53d4-b868-4a28-8436-f9112eb01c39
Depo-Testosterone is for intramuscular use only, given deep in the gluteal (buttock) muscle. It must not be given into a vein (Dosage and Administration).
The label says crystals that form in a cold vial can be redissolved by warming and shaking it, and the solution is inspected for particles before use.
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Use | Dose on the label | How often |
|---|---|---|
| Replacement in the hypogonadal male | 50-400 mg | Every two to four weeks |
| Inducing puberty in hypogonadal males | Various regimens; no single dose given | Adjusted to chronological and skeletal age |
Before starting, the diagnosis is confirmed by measuring serum testosterone in the morning on at least two separate days, with both results below the normal range.
The suggested dose varies with age, sex and diagnosis, and is adjusted according to the patient's response and the appearance of side effects.
For puberty induction, the label notes some experts start low and increase as puberty progresses, while others start higher and lower the dose for maintenance; age and bone age guide both.
Testosterone cypionate should not be used interchangeably with testosterone propionate because the two last different lengths of time.
Hemoglobin and hematocrit are checked periodically with long-term use.
Blood pressure is monitored periodically, especially in men with high blood pressure.
If urine blockage, priapism, excessive sexual stimulation or low sperm count appear, the label says to stop the androgen and, if restarted, use a lower dose.
The Depo-Testosterone label gives no missed-dose instruction. Ask your prescriber what to do if an injection is late.
More on this: missed a dose of Depo-Testosterone.
Not interchangeable with testosterone propionate, because of differences in how long each acts.
In Dose Track you set up Depo-Testosterone as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.