Short answer: The Testopel label dose guideline for androgen-deficient males is 150 mg to 450 mg implanted under the skin every 3 to 6 months. Each pellet holds 75 mg. The label sizes the dose at two 75 mg pellets for each 25 mg of testosterone propionate needed weekly by injection, and says the effect usually lasts three to four months, sometimes six.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Testopel is approved for: Testopel is approved as testosterone replacement in males with low or absent natural testosterone due to primary hypogonadism (testicular failure) or hypogonadotropic hypogonadism (a pituitary or hypothalamus cause). It may also be used to start puberty in carefully selected boys with clearly delayed puberty. The label says safety and effectiveness in men with age-related ("late-onset") hypogonadism have not been established (Indications and Usage).
Source
TESTOPEL (testosterone pellets) for subcutaneous implantation, prescribing information. Endo. DailyMed, version published July 24, 2025. DailyMed setid 03b9c0b1-5884-11e4-8ed6-0800200c9a66
Testopel pellets are implanted under the skin (subcutaneously). Each pellet is 3.2 mm across, about 9 mm long, and contains 75 mg of testosterone (Description).
Before starting, the diagnosis is confirmed by measuring serum testosterone in the morning on at least two separate days, with both results below the normal range (Dosage and Administration).
Pellets come one per vial, in boxes of 10 (NDC 66887-004-10) and 100 (NDC 66887-004-20) (How Supplied).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Item | What the label says |
|---|---|
| Dose guideline | 150 mg to 450 mg subcutaneously every 3 to 6 months |
| Pellet count rule | Two 75 mg pellets for each 25 mg testosterone propionate required weekly |
| Example: 75 mg per week by injection | Usually 450 mg (6 pellets) |
| Example: 50 mg per week by injection | 300 mg (4 pellets) may suffice for approximately three months |
| Absorption | About one-third in month 1, one-fourth in month 2, one-sixth in month 3 |
| How long it lasts | Ordinarily three to four months, sometimes as long as six months |
| Delayed puberty | Generally the lower range, for a limited time, for example 4 to 6 months |
The dose varies with age and diagnosis, and is adjusted according to the patient's response and the appearance of side effects.
Pellet implantation is much less flexible for dose changes than oral or injected testosterone, so great care is used when estimating the amount needed.
Blood pressure is monitored periodically, especially in men with high blood pressure.
In boys treated for delayed puberty, bone age is checked by hand and wrist x-ray every 6 months.
The Testopel label gives no missed-dose instruction. Pellets release testosterone over months; the label says the effect ordinarily lasts three to four months, sometimes six. Ask your prescriber when the next implantation is due.
The number of pellets is based on the weekly testosterone propionate dose a patient needs by injection: two 75 mg pellets for each 25 mg needed weekly.
In Dose Track you set up Testopel as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.