Short answer: If it has been 3 days or less since the missed dose, the Ngenla label says to give it as soon as possible. If more than 3 days have passed, skip it and give the next dose on the regular day. The weekly day can be changed only if the last dose was 3 or more days before.
| Situation | What the label says |
|---|---|
| Schedule | Once weekly, same day each week, any time of day (2.1) |
| 3 days or less after the missed dose | Give it as soon as possible (2.4) |
| More than 3 days | Skip it; give the next dose on the usual day (2.4) |
| Changing the weekly day | Allowed if the last dose was 3 or more days before (17) |
| Effective half-life | About 37.7 hours (12.3) |
Section 2.4 of the Ngenla prescribing information says that if a dose is missed, give Ngenla as soon as possible within 3 days after the missed dose. Then continue on the regular weekly day.
Example: your child's Ngenla day is Saturday and you remember on Monday. That is 2 days, so under the label you would give it Monday and the next one on Saturday.
Section 2.4 says to skip the missed dose and give the next dose on the regularly scheduled day. If you remember on Wednesday (4 days late), you would skip it and inject on Saturday.
Yes. The patient counseling section says the day of the week can change as long as the last dose was given 3 or more days before. After choosing the new day, continue once a week.
The label gives an effective half-life of about 37.7 hours in children with growth hormone deficiency, and says somatrogon is present in the blood for about 8 days after the last dose (section 12.3).
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.