Short answer: The Ngenla label dose is 0.66 mg/kg of actual body weight, injected under the skin once a week on the same day each week, at any time of day. The dose is then individualized by growth response. A missed dose can be given within 3 days; after that it is skipped. Children switching from daily growth hormone start the day after their last daily injection.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Ngenla is approved for: Ngenla is a once-weekly growth hormone analog approved for children aged 3 years and older who have growth failure because their bodies do not make enough growth hormone (section 1). It is not approved for adults.
Source
NGENLA (somatrogon-ghla) injection, for subcutaneous use, prescribing information and Patient Information. Pfizer. DailyMed, version published August 19, 2026. DailyMed setid 06dce529-b741-4a1b-8842-3ad77be6e308
Ngenla is injected under the skin (subcutaneously) once weekly, on the same day each week, at any time of day, in the abdomen, thighs, buttocks or upper arms, rotating the site weekly (section 2.1).
Prefilled pens deliver the dose in 0.2 mg (24 mg pen) or 0.5 mg (60 mg pen) steps. If a dose needs more than one injection, each goes in a different site (sections 2.1, 2.3 and 3).
The pen is not shaken, since shaking can damage the medicine. An eye (fundoscopic) exam is done before starting (sections 2.1 and 2.2).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Item | What the label says |
|---|---|
| Recommended dosage | 0.66 mg/kg based on actual body weight administered once weekly |
| 24 mg/1.2 mL (20 mg/mL) pen | Delivers a dose in 0.2 mg increments |
| 60 mg/1.2 mL (50 mg/mL) pen | Delivers a dose in 0.5 mg increments |
| Changing the weekly day | Allowed as long as the time between 2 doses is at least 3 days |
The dose is individualized for each child based on growth response.
The day of the weekly dose can be changed if needed, as long as at least 3 days pass between 2 doses; weekly dosing then continues on the new day.
If intracranial hypertension is confirmed, Ngenla is restarted at a lower dose once the signs have resolved.
Ngenla is not used once the growth plates (epiphyses) have closed.
A missed dose is given as soon as possible within 3 days after the missed dose. If more than 3 days have passed, the missed dose is skipped and the next dose given on the regularly scheduled day.
More on this: missed a dose of Ngenla.
Children switching from daily growth hormone may start once-weekly Ngenla on the day after their last daily injection.
In Dose Track you set up Ngenla as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.