Short answer: If it has been 12 hours or less since the usual injection time, the Voxzogo label says the missed dose can still be given. If more than 12 hours have passed, skip it and give the next daily dose on the usual schedule. Do not give two doses to catch up.
| Situation | What the label says |
|---|---|
| Schedule | Once daily, about the same time each day (2.2) |
| 12 hours or less late | Give the missed dose (2.2) |
| More than 12 hours late | Skip it; give the next daily dose as usual (2.2) |
| Dose | Based on body weight (2.2, Table 1) |
| Half-life | About 21 to 28 minutes (12.3) |
Section 2.2 says that if a dose of Voxzogo is missed, it can be given within 12 hours of the scheduled time. The Patient Information says the same.
Example: you usually inject at 7 p.m. and remember at 6 a.m. the next morning. That is 11 hours, so under the label you can still give it, then give the next dose at 7 p.m. as usual.
Section 2.2 says beyond 12 hours, skip the missed dose and give the next daily dose on the usual schedule. If you remember at 9 a.m. (14 hours late), you would wait for 7 p.m.
Vosoritide is very short-acting: the label gives a mean half-life of about 21 to 28 minutes (section 12.3). The daily schedule matters more than for a long-acting drug, and a 12-hour cutoff keeps two doses from landing close together.
Voxzogo is mixed before each injection, and each vial gives one dose. The label says a mixed vial can be kept at room temperature for at most 3 hours and any unused portion is thrown away. A missed dose cannot be saved in a mixed vial for later.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.