Missed an Increlex Dose? Never Make It Up (FDA)
[Missed dose · Increlex]

My child missed an Increlex dose. What should we do?

mecasermin (IGF-1) injection · Twice daily injection, shortly before or after a meal or snack · Label checked

Short answer: The Increlex label says that if one or more doses are missed, do not increase the next doses to make up for them. The Patient Information also says to skip a dose if your child cannot eat for any reason, because Increlex can lower blood sugar. It is given twice daily with a meal or snack.

What does the Increlex label say about missed doses?

From the FDA label on DailyMed. Numbers in brackets are label section numbers.
SituationWhat the label says
ScheduleTwice daily, shortly before or after a meal or snack (2.1)
Missed one or more dosesDo not increase later doses to make up (2.1)
Child cannot eatSkip that dose (Patient Information)
Main riskLow blood sugar (hypoglycemia) (5.1)
Late doseNo late window in the label

What does the Increlex label say about a missed dose?

Section 2.1 says that if one or more doses of Increlex are missed, do not increase the next doses to make up for the omitted ones. The Patient Information says not to give an extra dose or increase the amount to make up for a missed dose.

Example: your child's doses are with breakfast and dinner, and the breakfast dose was missed. Under the label the dinner dose stays the usual amount. The label does not give a window for giving the morning dose late, so ask your child's doctor.

Why must Increlex be skipped if my child cannot eat?

Increlex has insulin-like effects. The label warns that severe low blood sugar, including seizures, has happened with Increlex and says to give it shortly before or after a meal or snack. The Patient Information says to skip the dose if your child cannot eat for any reason.

What if we missed several days of Increlex?

The Increlex label does not say how to restart after several days. That is a question for your prescriber.

The label starts at a low dose and increases weekly if tolerated, with blood sugar checks at the start (section 2.1). Ask before restarting at the full dose.

This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.

Missed-dose rules for other medicines

Frequently asked questions

Can we give a double Increlex dose at the next meal?+
No. Section 2.1 says not to increase later doses to make up for missed ones.
What if my child is sick and not eating?+
The Patient Information says to skip the Increlex dose if your child cannot eat for any reason.
Is Increlex the same as IGF-1 LR3?+
No. Increlex is FDA-approved mecasermin (human IGF-1). IGF-1 LR3 is a research peptide with no FDA label and no official missed-dose rule.