Short answer: If the dose is less than 12 hours late, the Yorvipath label says to take it as soon as possible. If it is more than 12 hours late, skip it and take the next dose as scheduled. If treatment stops for 3 days or more, the label says your doctor should check for low calcium.
| Situation | What the label says |
|---|---|
| Schedule | Once daily |
| Less than 12 hours late | Take it as soon as possible (2.5) |
| More than 12 hours late | Skip it; take the next dose as scheduled (2.5) |
| Interrupted 3 days or more | Check for low calcium; resume the prior dose (2.5) |
| Half-life | About 60 hours for the released PTH (12.3) |
Section 2.5 says to take Yorvipath as soon as possible if a dose is missed by less than 12 hours. The Medication Guide says the same.
Example: you inject at 8 a.m. and remember at 5 p.m. That is 9 hours, so under the label you would inject at 5 p.m. and take the next dose at 8 a.m. tomorrow.
Section 2.5 says to skip the missed dose and take the next dose as scheduled. If you remember at 10 p.m. (14 hours late), you would wait until 8 a.m.
Section 2.5 says that if treatment is delayed or stopped for 3 days or more, the patient should be checked for signs of low calcium, and serum calcium may be measured. Calcium and active vitamin D may need to be restarted or increased. Yorvipath is then resumed at the previous dose as soon as possible, with a calcium test 7 to 10 days later.
Low calcium can cause tingling, muscle cramps or spasms. Tell your doctor about any gap of 3 days or more.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.