Short answer: The Gattex label says to take a missed dose as soon as possible on that same day, and never to take 2 doses on the same day. The Medication Guide adds: take your next dose the next day at your usual time. So the cutoff is the end of the day, not a set number of hours.
| Situation | What the label says |
|---|---|
| Schedule | Once daily, 0.05 mg/kg (2.2) |
| Missed a dose, same day | Take it as soon as possible that day (2.2) |
| Next day | Usual dose at the usual time (Medication Guide) |
| Doubling up | Never 2 doses on the same day (2.2) |
| Half-life | About 2 hours in healthy people, 1.3 hours in short bowel syndrome (12.3) |
Section 2.2 says that if a dose is missed, take it as soon as possible on that day, and do not take 2 doses on the same day. The Medication Guide says: take it as soon as you remember that day, then take your next dose the next day at your usual time.
Example: you inject Gattex at 8 a.m. and remember at 9 p.m. It is still the same day, so under the label you would inject at 9 p.m. and take the next dose at 8 a.m. tomorrow. If you remember only the next morning, you take one dose, not two.
Teduglutide has a short half-life, about 2 hours in healthy people and 1.3 hours in people with short bowel syndrome (section 12.3). The label's "same day" rule keeps it to one dose per day.
The Gattex label does not say how to restart after several missed days. That is a question for your prescriber.
If you also get IV nutrition or fluids, tell your care team about missed days, since they track those volumes closely.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.