[GLP-1 · Wegovy pill · FDA label guide]

Wegovy pill (semaglutide) dose schedule, titration chart and side effects

Novo Nordisk · Once daily tablet · Label reviewed as of

Short answer: Per the FDA label, the Wegovy pill starts at 1.5 mg once daily for days 1–30, then 4 mg for days 31–60 and 9 mg for days 61–90, reaching 25 mg once-daily maintenance on day 91 (2.3, Table 2). The label's schedule calls for one tablet each morning on an empty stomach with up to 4 ounces of water.

Per label section 1, Wegovy tablets are used with a reduced-calorie diet and increased physical activity to reduce the risk of major adverse cardiovascular events in adults with established cardiovascular disease and obesity or overweight, and to reduce excess body weight and maintain weight reduction long term in adults with obesity, or with overweight plus at least one weight-related condition. This page summarizes the current FDA prescribing information (revised 6/2026). It is not personalized medical advice; your prescriber sets your dose.

What is the Wegovy pill dose schedule?

The label's dosing schedule (label section 2.3, Table 2):

Dosing schedule as written in the FDA label (label section 2.3, Table 2).
PeriodDoseLabel note
Days 1–301.5 mg once dailyStarting dosage
Days 31–604 mg once dailyDosage escalation
Days 61–909 mg once dailyDosage escalation
Day 91 onward25 mg once dailyMaintenance dosage

Maintenance: The label's recommended maintenance dosage is 25 mg once daily for cardiovascular risk reduction and weight reduction in adults, which is also the highest tablet strength (2.3, 3). The label limits use to one tablet per day (2.1).

  • The label says to follow the Table 2 escalation to reduce the risk of gastrointestinal adverse reactions (2.3).
  • If a dose is not tolerated during escalation, the label says to consider delaying escalation (2.3).
  • If 25 mg once daily is not tolerated, the label says to consider switching to Wegovy injection 1.7 mg once weekly (2.3, 2.5).
  • The safety and effectiveness of Wegovy tablets have not been established in pediatric patients (8.4).

What does the Wegovy pill titration calendar look like?

Below is the label schedule laid out period by period, using the earliest timing the label allows. The label lets prescribers stay at a step longer, so a real calendar is often slower. The blank columns are for your own record.

Wegovy pill titration calendar from the label schedule (label section 2.3, Table 2). Not a personalized plan.
PeriodLabel doseDateSite / timeWeightNotes
Days 1–301.5 mg once daily
Days 31–604 mg once daily
Days 61–909 mg once daily
Day 91 onward25 mg once daily

What strengths does Wegovy pill come in?

Wegovy pill tablet presentations (label section 3; 16).
ProductWhat it deliversDoses per pen / packContents
1.5 mg tablet1.5 mg per tabletBottle of 30 tabletsWhite to light yellow, round, debossed "1.5" and "novo"
4 mg tablet4 mg per tabletBottle of 30 tabletsWhite to light yellow, round, debossed "4" and "novo"
9 mg tablet9 mg per tabletBottle of 30 tabletsWhite to light yellow, round, debossed "9" and "novo"
25 mg tablet25 mg per tabletBottle of 30 tabletsWhite to light yellow, oval, debossed "25" and "novo"
  • Each step of the label's schedule uses its own tablet strength, and each bottle holds 30 tablets (3, 16).
  • Per the label, tablets are stored at 20°C to 25°C in the original bottle to protect them from moisture (16).
  • The tablets contain salcaprozate sodium (SNAC), which the label says facilitates absorption of semaglutide; absolute oral bioavailability is estimated at about 1% to 2% (12.3).

What are the most common Wegovy pill side effects?

The label reports these rates from placebo-controlled trials (label section 6.1). Percentages are the share of trial participants who reported each reaction.

The label has no separate adverse-reaction table for the tablet; it states that in the 64-week Study 7 the types and frequency of common adverse reactions with 25 mg tablets were similar to those in Table 3 (the injection table). The figures below are the tablet-specific rates the label reports in 6.1 (tablet safety population N=204; the placebo N for these rates is not stated in 6.1).
Adverse reactionPlaceboWegovy 25 mg tablet (N=204)
Stopped treatment due to adverse reactions5.9%6.9%
Stopped treatment due to gastrointestinal adverse reactions2%3.4%
Severe gastrointestinal adverse reactions0%2%
Dysesthesia (altered skin sensation)0%5%
Cholelithiasis (gallstones)1%2.5%

When do they happen? The label presents the 30-day escalation steps as a way to reduce the risk of gastrointestinal adverse reactions (2.3); it does not give a tablet-specific statement on when these reactions occur.

The label also carries warnings that are not in this table (for example, a boxed warning or pancreatitis and gallbladder warnings where applicable). Read the full label linked under Sources, and report side effects to your prescriber.

What if you miss a dose of Wegovy pill?

Per the label, a missed Wegovy tablet dose is skipped, and the next dose is taken the following day. The label limits use to one tablet per day (2.1). (label section 2.4) The full walk-through is on the Wegovy pill missed-dose page.

How is Wegovy pill taken?

The label describes one tablet once daily on an empty stomach in the morning with water (up to 4 ounces), and no other liquids. The tablet is swallowed whole, not split, crushed, chewed or dissolved, followed by a wait of at least 30 minutes before eating, drinking or taking other oral medications. In studies, absorption was higher with a longer post-dose fast (12.3). (label section 2.1; 12.3)

What should you track on Wegovy pill?

A simple log makes each titration step easier to talk through with your prescriber. These are the things worth writing down, and how Dose Track handles them:

  • Dose and date. Each tablet with its amount, so the titration steps above line up with what you actually took. Dose Track keeps the full history of every dose change.
  • Weight. Logged by hand or synced from Apple Health or Android Health Connect, and charted alongside your dose changes.
  • Side effects. A note of what you felt and when, so you can see whether it settles after a dose step and bring the record to your prescriber.
  • Reminders. A daily reminder at the time you choose.

Your log stays on your phone. See GLP-1 tracking in Dose Track for the full feature list.

Wegovy pill questions people ask

What's the highest dose of the Wegovy pill?+
The label's maintenance and highest tablet dose is 25 mg once daily, reached on day 91 of the schedule after 1.5 mg, 4 mg and 9 mg steps (2.3, Table 2). Tablets come in 1.5 mg, 4 mg, 9 mg and 25 mg strengths (3), and the label limits use to one tablet per day (2.1). Dose decisions belong to the prescriber.
How long does it take for the Wegovy pill to work?+
The label reports results at the trial endpoint rather than a time of onset. In Study 7, tablets were escalated to 25 mg over 12 weeks and then continued for 52 weeks; at week 64, mean body weight change was -13.6% with 25 mg tablets versus -2.4% with placebo, and 76.3% versus 31.3% lost at least 5% of body weight (14.2, Table 11). Figure 5 in the label plots the results.
Can you skip the 1.5 mg starter dose of the Wegovy pill?+
The label's schedule starts at 1.5 mg once daily for 30 days and says to follow the Table 2 escalation to reduce the risk of gastrointestinal adverse reactions (2.3). The one exception it describes is switching from Wegovy 2.4 mg injection: one week after the last injection, 25 mg tablets may be started directly (2.5). This is not personalized advice; dosing changes are for the prescriber.
What time of day should you take the Wegovy pill?+
The label says Wegovy tablets are taken once daily in the morning on an empty stomach, followed by a wait of at least 30 minutes before eating food, drinking beverages or taking other oral medications (2.1). In pharmacology studies, semaglutide absorption was higher after a longer post-dose fasting period (12.3).
Do you take the Wegovy pill with food or water?+
Per the label, the tablet is taken on an empty stomach with water only, up to 4 ounces, and no other liquids (2.1). Food, other drinks and other oral medicines wait at least 30 minutes (2.1). In pharmacology studies, absorption was higher with 50 mL than 240 mL of water and higher after a longer post-dose fast (12.3).
What happens if you miss a Wegovy pill?+
The label says a missed tablet dose is skipped and the next dose is taken the following day (2.4). It also states that no more than one tablet is taken per day (2.1), so the label does not describe doubling up.
Is the Wegovy pill the same as Wegovy injection?+
Both contain semaglutide and share one FDA label. The tablet is taken daily (25 mg maintenance) and the injection weekly (2.4 mg recommended maintenance) (2.2, 2.3). The label says 25 mg tablet levels are predicted to be comparable to 2.4 mg weekly injection, with more variability (12.3). Tablets are labeled only for adults and are not indicated for MASH (1, 6.1).
Can you switch from Wegovy injection to the pill?+
The label describes switching adults on Wegovy 2.4 mg injection (for cardiovascular risk reduction or weight reduction) to 25 mg tablets once daily, starting one week after the last injection (2.5). Going the other way, 2.4 mg weekly injection starts the day after the last 25 mg tablet, or 1.7 mg for patients who did not tolerate 25 mg tablets (2.5).