Short answer: If it has been 4 days (96 hours) or less since the missed dose, the Mounjaro label says to take it as soon as possible. If more than 4 days have passed, skip it and take the next dose on your usual day. Two doses should be at least 3 days (72 hours) apart.
| Situation | What the label says |
|---|---|
| Schedule | Once weekly (2.1) |
| Missed by 4 days (96 h) or less | Take it as soon as possible (2.1) |
| Missed by more than 4 days | Skip it; take the next dose on the usual day (2.1) |
| Minimum time between doses | At least 3 days (72 hours) (2.1) |
| Several weeks missed | No specific rule in the Mounjaro label |
| Changing your injection day | Allowed if doses stay at least 3 days apart (2.1) |
Section 2.1 of the Mounjaro prescribing information says that if a dose is missed, take it as soon as possible within 4 days (96 hours) after the missed dose. Then go back to your regular once-weekly schedule.
Example: your day is Friday and you remember on Monday (3 days late). Under the label you would inject Monday and again on Friday. Monday to Friday is 4 days, more than the 3-day minimum.
Skip the missed dose and take the next one on your regularly scheduled day. The 4-day window is shorter than Ozempic's 5 days because tirzepatide needs at least 3 days between doses.
No. The Medication Guide says not to take 2 doses of Mounjaro within 3 days of each other. Section 2.1 sets the same 3-day (72-hour) minimum when changing your weekly day.
The Mounjaro label does not give a separate rule for restarting after several missed weeks. Whether to resume your usual dose or restart at a lower one is a question for your prescriber, especially if stomach side effects were a problem when you first started.
For context, the label starts everyone at 2.5 mg once weekly and only increases in 2.5 mg steps after at least 4 weeks on a dose (section 2.1), a slow climb meant to reduce stomach side effects. Tirzepatide has an elimination half-life of about 5 days (section 12.3).
Yes, if needed, as long as the time between the two doses is at least 3 days (72 hours), per section 2.1.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.