Features Medications Blog Pricing Support Download
[GLP-1 · Foundayo · FDA label guide]

Foundayo (orforglipron) dose schedule, titration chart and side effects

Eli Lilly and Company · Once daily tablet · Label reviewed as of

Short answer: Per the FDA label, Foundayo starts at 0.8 mg by mouth once daily. After at least 30 days it rises to 2.5 mg, then to 5.5 mg after at least 30 more days. Based on response and tolerability, it may step to 9 mg, 14.5 mg, then 17.2 mg, each after 30+ days. The maximum is 17.2 mg daily (2.1).

Per label section 1, Foundayo is used with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults with obesity, or adults with overweight plus at least one weight-related comorbid condition. This page summarizes the current FDA prescribing information (revised 7/2026). It is not personalized medical advice; your prescriber sets your dose.

What is the Foundayo dose schedule?

The label's dosing schedule (label section 2.1):

Dosing schedule as written in the FDA label (label section 2.1).
PeriodDoseLabel note
At least 30 days0.8 mg once dailyStarting dosage
At least 30 days2.5 mg once daily
At least 30 days5.5 mg once dailyStep reached by everyone on the label schedule
At least 30 days9 mg once dailyOptional, based on treatment response and tolerability
At least 30 days14.5 mg once dailyOptional, based on treatment response and tolerability
Ongoing17.2 mg once dailyMaximum dosage; optional, based on treatment response and tolerability

Maintenance: The label escalates everyone to 5.5 mg once daily, then allows further increases to 9 mg, 14.5 mg, or 17.2 mg based on treatment response and tolerability; 17.2 mg once daily is the maximum (2.1). The weight-management trials studied 5.5 mg, 9 mg and 17.2 mg as assigned doses (14).

  • Each increase comes after at least 30 days on the current dosage, following the label schedule to reduce the risk of gastrointestinal adverse reactions (2.1).
  • With a strong CYP3A4 inhibitor, the label caps the dosage at 9 mg once daily; strong CYP3A4 inhibitors that also inhibit OATP1B, and strong CYP3A4 inducers, are to be avoided (2.2).
  • The label limits use to one tablet per day (2.1).

What does the Foundayo titration calendar look like?

Below is the label schedule laid out period by period, using the earliest timing the label allows. The label lets prescribers stay at a step longer, so a real calendar is often slower. The blank columns are for your own record.

Foundayo titration calendar from the label schedule (label section 2.1). Not a personalized plan.
PeriodLabel doseDateSite / timeWeightNotes
Days 1–30 (at least)0.8 mg once daily
Days 31–60 (at least)2.5 mg once daily
Days 61–90 (at least)5.5 mg once daily
Days 91–120 (if increased)9 mg once daily
Days 121–150 (if increased)14.5 mg once daily
Day 151 onward (if increased)17.2 mg once daily (maximum)

Printing this page prints the schedule and calendar without the site navigation.

What strengths does Foundayo come in?

Foundayo tablet presentations (label section 3; 16.1).
Tablet strengthAppearancePackImprint
0.8 mgPink, roundBottle of 30 tablets"L" / "G1"
2.5 mgLight yellow, roundBottle of 30 tablets"L" / "G2"
5.5 mgGrayish purple, roundBottle of 30 tablets"L" / "G3"
9 mgPink, modified ovalBottle of 30 tablets"Lilly" / "G4"
14.5 mgLight yellow, modified ovalBottle of 30 tablets"Lilly" / "G5"
17.2 mgGrayish purple, modified ovalBottle of 30 tablets"Lilly" / "G6"
  • Each dose level is its own tablet strength; the label says to swallow tablets whole and not break, crush, or chew them (2.1).
  • Bottles come with desiccant and a child-resistant closure; storage is at room temperature, 68–77°F (20–25°C), with excursions permitted to 59–86°F (15–30°C) (16.1, 16.2).

What are the most common Foundayo side effects?

The label reports these rates from placebo-controlled trials (label section 6.1, Table 1). Percentages are the share of trial participants who reported each reaction.

Adverse reactions in ≥5% of Foundayo-treated adults with obesity or overweight (with or without type 2 diabetes) and more often than placebo, pool of Trials 1 and 2 (label Table 1).
Adverse reactionPlacebo (N=1,576)Foundayo 5.5 mg (N=1,051)Foundayo 9 mg (N=1,055)Foundayo 17.2 mg (N=1,049)
Nausea10%26%34%35%
Constipation9%20%27%24%
Diarrhea11%21%23%25%
Vomiting4%13%21%24%
Dyspepsia4%12%16%13%
Abdominal pain7%13%14%14%
Headache7%8%9%9%
Abdominal distension3%7%9%8%
Fatigue4%6%7%9%
Eructation1%6%8%8%
Gastroesophageal reflux disease2%6%6%7%
Flatulence2%5%6%6%
Hair loss2%4%4%5%

When do they happen? The label states that the incidence of nausea, vomiting, and diarrhea was higher during the dosage escalation period and decreased over time (6.1). GI adverse reactions overall occurred in 60%, 68% and 69% of patients on 5.5 mg, 9 mg and 17.2 mg vs 37% on placebo (6.1). The trial data come from an investigational orforglipron formulation presented as equivalent Foundayo dosages (6.1).

The label also carries warnings that are not in this table (for example, a boxed warning or pancreatitis and gallbladder warnings where applicable). Read the full label linked under Sources, and report side effects to your prescriber.

What if you miss a dose of Foundayo?

Per the label, a missed dose is taken as soon as possible, without doubling up the next dose. If 7 or more consecutive doses are missed, the label says escalation is restarted at a lower dosage to reduce the risk of gastrointestinal adverse reactions. (label section 2.3)

How is Foundayo taken?

The label describes one tablet by mouth once daily, with or without food, swallowed whole (not broken, crushed, or chewed), and no more than one tablet per day. The label does not specify a time of day. It reports no clinically relevant food effect on orforglipron exposure (12.3). (label section 2.1)

What should you track on Foundayo?

A simple log makes each titration step easier to talk through with your prescriber. These are the things worth writing down, and how Dose Track handles them:

  • Dose and date. Each tablet with its amount, so the titration steps above line up with what you actually took. Dose Track keeps the full history of every dose change.
  • Weight. Logged by hand or synced from Apple Health or Android Health Connect, and charted alongside your dose changes.
  • Side effects. A note of what you felt and when, so you can see whether it settles after a dose step and bring the record to your prescriber.
  • Reminders. A daily reminder at the time you choose.

Your log stays on your phone. See GLP-1 tracking in Dose Track for the full feature list.

Half-life calculatorEstimate levels after your last dose GLP-1 tracking in Dose TrackDoses, titration, weight and sites

Foundayo questions people ask

What's the highest dose of Foundayo?+
The label lists 17.2 mg once daily as the maximum dosage (2.1). It is the last of six tablet strengths (0.8, 2.5, 5.5, 9, 14.5 and 17.2 mg), and steps above 5.5 mg are based on treatment response and tolerability. When a strong CYP3A4 inhibitor is used at the same time, the label caps Foundayo at 9 mg once daily (2.2).
How long does it take for Foundayo to work?+
The label reports that steady-state blood levels are reached after about 1 week of daily dosing (12.3). The weight-management trials measured their primary result at week 72: in Trial 1 (adults without diabetes), mean weight change was -7.4%, -8.3% and -11.1% on 5.5, 9 and 17.2 mg vs -2.1% on placebo (14, Table 6).
Can you skip the 0.8 mg starter dose of Foundayo?+
The label's schedule starts at 0.8 mg once daily for at least 30 days, then 2.5 mg for at least 30 days, before 5.5 mg, and says to follow this escalation to reduce the risk of gastrointestinal adverse reactions (2.1). The trials used the same escalation (14). This is general label information, not personalized advice; dosing changes are for the prescriber.
What time of day should you take Foundayo?+
The label says Foundayo is taken by mouth once daily, with or without food, but it does not name a specific time of day (2.1). The Medication Guide likewise describes taking it 1 time each day and not taking 2 doses in the same day.
Do you take Foundayo with food?+
Per the label, Foundayo can be taken with or without food (2.1). In a food-effect study, the label reports no clinically relevant food effect on orforglipron exposure; with food, AUC fell 19% and peak concentration fell 26% vs fasting, with no change in time to peak or half-life (12.3).
How long is the Foundayo titration?+
On the label schedule, each step lasts at least 30 days: 0.8 mg, then 2.5 mg, then 5.5 mg, so the earliest arrival at 5.5 mg is after about 60 days (2.1). Further optional steps to 9 mg, 14.5 mg and 17.2 mg each also follow at least 30 days on the prior dose, making day 151 the earliest point for 17.2 mg.
Does Foundayo affect birth control pills?+
The label advises patients using oral hormonal contraceptives to switch to a non-oral method or add a barrier method for 30 days after starting Foundayo and for 30 days after each dose escalation, because delayed gastric emptying may affect absorption (7.3, 8.3). It states that non-oral hormonal contraceptives should not be affected.
How many tablets come in a Foundayo bottle?+
The label lists every strength (0.8, 2.5, 5.5, 9, 14.5 and 17.2 mg) in bottles of 30 tablets, with desiccant and a child-resistant closure (16.1). The label limits use to one tablet per day (2.1), and storage is at room temperature (16.2).

Sources

Reviewed as of . Section numbers above refer to the FDA prescribing information.

  1. Foundayo (orforglipron) tablets — FDA label, DailyMed (revised 7/2026)
  2. Drugs@FDA — NDA 220934 (Foundayo) approval history

All GLP-1 brand guides · GLP-1 tracking · Supported medications