Short answer: Ovidrel is a single 250 µg injection under the skin, given one day after the last dose of the follicle stimulating medicine, for both IVF and ovulation induction. The label says it is not given until estradiol and vaginal ultrasound show enough follicle development, and it is withheld if the ovaries respond too strongly.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Ovidrel is approved for: Ovidrel is a recombinant hCG used as the final trigger for egg maturation and early luteinization in infertile women in an assisted reproduction program such as IVF, after pituitary desensitization and pretreatment with follicle stimulating hormone. It is also used to induce ovulation and pregnancy in anovulatory infertile women whose infertility is functional and not due to primary ovarian failure (Indications and Usage).
Source
OVIDREL PreFilled Syringe (choriogonadotropin alfa injection), for subcutaneous use, prescribing information. EMD Serono. DailyMed, version published December 28, 2023. DailyMed setid a683e58a-63ea-44b8-a326-1a99a537bcf2
Ovidrel is for subcutaneous use only and comes as a single-dose prefilled syringe; any unused medicine is discarded (Dosage and Administration).
It may be self-injected. The label's steps describe cleaning a site on the stomach with an alcohol wipe, injecting the prescribed dose and pressing gauze on the site (Dosage and Administration).
Before dispensing it is stored refrigerated. A patient may keep it at room temperature up to 77°F (25°C) for no more than 30 days, protected from light (How Supplied).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Use | Dose and timing on the label |
|---|---|
| Assisted reproductive technologies (ART) | 250 µg one day following the last dose of the follicle stimulating agent |
| Ovulation induction (OI) | 250 µg one day following the last dose of the follicle stimulating agent |
| When to give | Not until adequate follicular development is indicated by serum estradiol and vaginal ultrasonography |
| When to withhold | Excessive ovarian response: clinically significant ovarian enlargement or excessive estradiol production (and, in OI, multiple follicular development) |
If the ovaries are abnormally enlarged on the last day of FSH therapy, Ovidrel is not given in that cycle, to lower the risk of OHSS.
Women are followed for at least two weeks after hCG is given, because OHSS develops quickly and usually peaks 7 to 10 days later.
Ultrasound and estradiol are used together to time the trigger and to watch for ovarian enlargement and multiple pregnancy risk; the number of growing follicles is confirmed by ultrasound.
Ovidrel is a single trigger injection timed to follicle development, and the label gives no missed-dose instruction. Ask your prescriber or clinic what to do if the injection was not given at the planned time.
In Dose Track you set up Ovidrel as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.