Clomiphene citrate is a selective estrogen receptor modulator (SERM) sold as Clomid. It is a mix of two isomers, zuclomiphene (cis) and enclomiphene (trans).
Also known as: Clomid.
Clomid and generic clomiphene citrate come as 50 mg tablets.
The FDA label approves clomiphene only for ovulatory dysfunction in women who want to become pregnant, at 50 mg daily for 5 days, increasing to at most 100 mg daily for 5 days in a later course. Use in men is off-label: the label says there are no adequate, well-controlled studies showing it works for male infertility, and reports testicular tumors and gynecomastia in men.
The Endocrine Society 2018 guideline notes clomiphene has been used empirically in men, but that neither its efficacy nor its safety has been shown in randomized trials. The AUA 2018 guideline says clinicians may use SERMs, hCG or aromatase inhibitors in men with testosterone deficiency who want to maintain fertility (a conditional recommendation). Whether to take it, and how much, is a decision for you and your prescriber. For the single-isomer version, see enclomiphene and hCG vs enclomiphene.
The FDA Clomid label gives no single half-life. It says the zuclomiphene isomer has a longer half-life than enclomiphene and has been detected for more than a month after a dose, so we do not list one number.