Short answer: The Leqvio label says that if a planned dose is missed by less than 3 months, give it and keep the original schedule. If it is missed by more than 3 months, restart with a new schedule: a dose now, another at 3 months, then every 6 months. Leqvio is given by a healthcare professional.
| Situation | What the label says |
|---|---|
| Schedule | 284 mg at the start, at 3 months, then every 6 months (2.1) |
| Missed by less than 3 months | Give it; keep the original schedule (2.1) |
| Missed by more than 3 months | Restart: dose now, again at 3 months, then every 6 months (2.1) |
| Who gives it | A healthcare professional (2.2) |
| LDL check | Any time from about 30 days, regardless of dose timing (2.1) |
Section 2.1 says that if a planned dose is missed by less than 3 months, give Leqvio and keep dosing on the original schedule.
Example: your 6-monthly doses are due in January and July, and the July dose is given in September (2 months late). Under the label the next dose is still due the following January.
Section 2.1 says to restart with a new schedule: give Leqvio, then again at 3 months, then every 6 months. In the example, if the July dose is given in November (4 months late), the next one would be due in February and then every 6 months after that.
Inclisiran leaves the blood quickly, with a half-life of about 9 hours (section 12.3), but it works inside liver cells and its effect on LDL lasts for months. The label also says LDL can be checked any time from about 30 days after starting, regardless of when the last dose was.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.