ARA-290 Reconstitution Calculator, Units & Half-Life
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[Peptide · Compound guide]

ARA-290 (Cibinetide): reconstitution, units and half-life

Vial sizes · Worked example · Units chart · Half-life notes

What is ARA-290?

ARA-290 (cibinetide) is a small peptide designed from the structure of erythropoietin (EPO). It acts on a tissue-repair receptor without stimulating red blood cell production. It has been in phase 2 trials and is not FDA approved.

Also known as: Cibinetide.

Common vial sizes

Powder vials are usually labeled 10 mg.

Water and syringe-unit charts by vial size: 10 mg

Worked reconstitution example

Here is the math for a 10 mg vial mixed with 2 mL of bacteriostatic water, drawing 4 mg with a U-100 insulin syringe (1 mL = 100 units).

  1. Concentration. 10 mg ÷ 2 mL = 5 mg/mL
  2. Volume to draw. 4 mg ÷ 5 mg/mL = 0.8 mL
  3. Syringe units. 0.8 mL × 100 = 80 units
The amount here is an example to show the math, not a recommendation. How much to take is a decision for you and your prescriber.

Units chart at 5 mg/mL

10 mg vial + 2 mL water. Amounts are examples for the conversion, not doses.
AmountVolumeU-100 syringe
2 mg0.4 mL40 units
4 mg0.8 mL80 units
8 mg1.6 mL160 units (over 1 mL)

Same amount, different water volumes

Adding more water doesn't change how much ARA-290 is in the vial. It only spreads it over more liquid, so each draw is bigger and easier to read.

4 mg from a 10 mg vial.
Water addedConcentrationVolumeU-100 syringe
1 mL10 mg/mL0.4 mL40 units
2 mL5 mg/mL0.8 mL80 units

For any other vial size or amount, the free peptide reconstitution calculator works backwards from the amount you want and suggests a water volume that lands on a clean syringe mark.

What doses of ARA-290 were studied?

In a phase 2 trial in type 2 diabetes with painful neuropathy (Brines 2015), people injected 4 mg under the skin daily for 28 days or placebo; no safety issues were identified. In a phase 2b trial in 64 people with sarcoidosis-related small nerve fiber loss (Culver 2017), daily doses of 1, 4 or 8 mg for 28 days were compared with placebo; the 4 mg group had the clearest increase in corneal nerve fibers.

These are trial protocols, not personalized advice; confirm any dosing with your prescriber.

ARA-290 half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not open a primary human source with a half-life for ARA-290, so we do not list one here.

How to track ARA-290 in Dose Track

  1. Add ARA-290 as a custom compound. It is not in the built-in list, but a custom compound gets the same vial, units and reminder tools, and it sits next to everything else you take.
  2. Save your vial: enter the vial size and how much water you added. From then on every amount you log shows as syringe units, and the reconstitution planner suggests a water volume that lands on a clean mark.
  3. Log each shot. The app subtracts it from the vial, shows what is left, and warns you before you run out.
  4. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  5. Your log stays on your phone.
BPC-157Body Protection Compound 157 Thymosin Alpha-1Thymalfasin, Zadaxin · half-life about 2 hours KPVLys-Pro-Val

Frequently asked questions

How much bacteriostatic water do I add to a 10 mg ARA-290 vial?+
There is no single right amount. More water makes each draw bigger and easier to measure; less water makes it smaller. For example, 2 mL in a 10 mg vial gives 5 mg/mL, so 4 mg is 0.8 mL, or 80 units on a U-100 insulin syringe. That amount is only an example for the math, not a recommendation. The free Dose Track reconstitution calculator works it out for any vial and amount.
How many units is 4 mg of ARA-290?+
It depends on the concentration in your vial. At 5 mg/mL (10 mg mixed with 2 mL), 4 mg is 0.8 mL, which is 80 units on a U-100 insulin syringe, where 1 mL is 100 units. Divide the amount by the concentration to get mL, then multiply by 100.
What is the half-life of ARA-290?+
We could not open a primary human source with a half-life for ARA-290, so we do not list one here.
Can I track ARA-290 in Dose Track?+
Yes, as a custom compound. ARA-290 is not in the built-in list, but you can add it yourself. You can then log each shot next to your other compounds, save your vial and how much water you added so every amount shows in syringe units, see how much is left in the vial, and get reminders. Your log stays on your phone.

Sources

  1. Brines M, et al. ARA 290, a nonerythropoietic peptide engineered from erythropoietin, in patients with type 2 diabetes: a phase 2 study. Mol Med. 2015.
  2. Culver DA, et al. Cibinetide improves corneal nerve fiber abundance in patients with sarcoidosis-associated small nerve fiber loss and neuropathic pain. Invest Ophthalmol Vis Sci. 2017.

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