How to Store SymlinPen (Pramlintide): 30 Days
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[Storage · Symlin]

How to store SymlinPen (pramlintide)

Quoted from the US label · Unopened vs in use · Travel · Sources · Reviewed

Short answer: Keep unused SymlinPens in the fridge at 36-46°F (2-8°C), away from light. After first use, a pen can be kept in the fridge or at up to 86°F (30°C) and must be used within 30 days either way. Do not freeze it, and do not use it if it has been frozen. Let it reach room temperature before injecting. Source: Symlin label, section 16 and Table 9.

What does the Symlin label say?

Section 16: “SYMLIN pen-injectors not in use: Refrigerate (2°C to 8°C; 36°F to 46°F), and protect from light. Do not freeze. Do not use if product has been frozen.”

“SYMLIN pen-injectors in use: After first use, refrigerate or keep at a temperature not greater than 86°F (30°C) for 30 days. Use within 30 days, whether or not refrigerated.”

Symlin US prescribing information, Table 9 (1.5 mL and 2.7 mL pen-injectors).
StageStorageLimit
Unopened (not in use)RefrigeratedUntil the expiration date
Open (in use)Refrigerated or up to 86°F (30°C)Use within 30 days

How do you handle a SymlinPen in use?

  • Let it come to room temperature before injecting; the label says this helps reduce injection site reactions.
  • Do not store the pen with the needle attached or with the knob pulled out, to prevent air bubbles.
  • Throw away a used pen after 30 days even if medicine is left.
  • Never mix Symlin and insulin: the label says they must always be given as separate injections (section 5.4).

Pramlintide is an amylin analog, the same drug class as cagrilintide. See amylin analog and the cagrilintide page; cagrilintide has no FDA label.

What if a SymlinPen froze or got hot?

Frozen: do not use it (section 16 and Medication Guide). Hot: the in-use range stops at 86°F (30°C); the label gives no allowance above that. Ask your pharmacist.

How do you travel with it?

An in-use SymlinPen can travel unrefrigerated at up to 86°F (30°C) within its 30 days. Unused spares stay cold.

  • TSA allows medically necessary liquids over 3.4 oz in carry-on bags; declare them at the checkpoint for inspection.
  • Unused syringes and pen needles are allowed when they travel with the injectable medicine.
  • Ice packs and gel packs that keep medicine cool may go through frozen, partly frozen or melted.
  • Keep medicine in your carry-on, not checked luggage, where you cannot control the temperature. Do not let it touch an ice pack directly, since most labels say do not freeze.

More in the travel guide.

Quoted from the current US label on DailyMed, not personalized advice. Labels change; the leaflet in your own carton, your pharmacist and your prescriber are the final word on how to store it.
LantusUnopened in the fridge; 28 days once opened; in-use SoloStar pens at room temperature only. Left out of the fridgeExact room-temperature hours and days from each label, and the temperature ceiling. Can you freeze peptides?Every "do not freeze" statement on the labels, and lyophilized vs mixed.

Frequently asked questions

Does Symlin need to be refrigerated after opening?+
No. After first use it can be refrigerated or kept at up to 86°F (30°C), and must be used within 30 days either way.
How long is a SymlinPen good after first use?+
30 days, whether or not it is refrigerated.
Can I use Symlin after it froze?+
No. The label says do not use it if it has been frozen.

Sources

  1. SymlinPen (pramlintide acetate) US prescribing information, DailyMed
  2. TSA: Liquid medications
  3. TSA: Unused syringes
  4. TSA: Gel ice packs

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