Short answer: Store unopened Imcivree vials in the fridge at 36-46°F (2-8°C), in the carton. After leaving the fridge, a vial may be kept anywhere from 36°F to 77°F (2-25°C) for up to 30 days, with brief excursions to 86°F (30°C). Once a vial is punctured, discard it after 30 days. Throw away Imcivree stored above 86°F. Source: Imcivree label, section 16, Table 19.
Section 16: “Store unopened IMCIVREE vials in the refrigerator at 2°C to 8°C (36°F to 46°F) in the original carton. After removal from the refrigerator, vials may be kept at temperatures ranging from refrigerated to room temperature (2°C to 25°C [36°F to 77°F]) for up to 30 days with brief excursions up to 30°C (86°F). After the vial is punctured (opened), discard after 30 days.”
| Storage | Unopened vial | Opened vial |
|---|---|---|
| 36-46°F (2-8°C) | Until the expiration date | Up to 30 days, or expiry if sooner |
| 36-77°F (2-25°C), excursions to 86°F | Up to 30 days, or expiry if sooner | Up to 30 days, or expiry if sooner |
| Above 86°F (30°C) | Discard and do not use | Discard and do not use |
Section 2.5: take it out of the fridge about 15 minutes before injecting, or roll the vial gently between your palms for 60 seconds. Keep opened and unopened vials in the carton to protect them from light. Vials may go back into the fridge.
Setmelanotide is a melanocortin-4 receptor agonist, related in class to bremelanotide. The reconstitution calculator can convert mg to syringe units for a 10 mg/mL solution.
Instructions for Use: “Throw away IMCIVREE that has been stored above 86°F (30°C).” Also throw away a vial 30 days after it first left the fridge, even if never opened.
Imcivree can travel between 36°F and 77°F (2-25°C) for up to 30 days, which covers most trips without a fridge. Keep it in the carton and away from hot cars.
More in the travel guide.