Mazdutide Reconstitution Calculator, Units & Half-Life
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[GLP-1 · Compound guide]

Mazdutide: reconstitution, units and half-life

Vial sizes · Worked example · Units chart · Half-life notes

What is mazdutide?

Mazdutide is a once-weekly injection that acts on GLP-1 and glucagon receptors, developed by Innovent Biologics with Eli Lilly. It was approved in China in June 2025 as Xinermei for weight management and is not FDA approved.

Also known as: Xinermei.

Common vial sizes

There is no FDA-approved mazdutide product. Powder vials are usually labeled 5 mg or 10 mg.

Water and syringe-unit charts by vial size: 5 mg · 10 mg

Worked reconstitution example

Here is the math for a 10 mg vial mixed with 2 mL of bacteriostatic water, drawing 4 mg with a U-100 insulin syringe (1 mL = 100 units).

  1. Concentration. 10 mg ÷ 2 mL = 5 mg/mL
  2. Volume to draw. 4 mg ÷ 5 mg/mL = 0.8 mL
  3. Syringe units. 0.8 mL × 100 = 80 units
The amount here is an example to show the math, not a recommendation. How much to take is a decision for you and your prescriber.

Units chart at 5 mg/mL

10 mg vial + 2 mL water. Amounts are examples for the conversion, not doses.
AmountVolumeU-100 syringe
2 mg0.4 mL40 units
4 mg0.8 mL80 units
8 mg1.6 mL160 units (over 1 mL)

Same amount, different water volumes

Adding more water doesn't change how much mazdutide is in the vial. It only spreads it over more liquid, so each draw is bigger and easier to read.

4 mg from a 10 mg vial.
Water addedConcentrationVolumeU-100 syringe
1 mL10 mg/mL0.4 mL40 units
2 mL5 mg/mL0.8 mL80 units

For any other vial size or amount, the free peptide reconstitution calculator works backwards from the amount you want and suggests a water volume that lands on a clean syringe mark.

What doses of mazdutide were studied?

In the phase 3 GLORY-1 trial (Ji, NEJM 2025; 610 adults in China with overweight or obesity, 48 weeks), people took 4 mg or 6 mg once weekly or placebo. Mean weight change at week 48 was −11.0% on 4 mg and −14.0% on 6 mg, versus +0.3% on placebo. Side effects were mostly gastrointestinal and mild to moderate.

The GLORY-2 trial (JAMA 2026) tested a higher 9 mg dose in Chinese adults with obesity. In June 2025 China approved mazdutide for long-term weight management, and in September 2025 for blood-sugar control in type 2 diabetes.

These are trial protocols, not personalized advice; confirm any dosing with your prescriber.

Mazdutide half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not open a primary human pharmacokinetic paper for mazdutide, so we do not list a half-life or time to peak here.

How to track mazdutide in Dose Track

  1. Add mazdutide as a custom compound. It is not in the built-in list, but a custom compound gets the same vial, units and reminder tools, and it sits next to everything else you take.
  2. Save your vial: enter the vial size and how much water you added. From then on every amount you log shows as syringe units, and the reconstitution planner suggests a water volume that lands on a clean mark.
  3. Log each shot. The app subtracts it from the vial, shows what is left, and warns you before you run out.
  4. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  5. Your log stays on your phone.
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Frequently asked questions

How much bacteriostatic water do I add to a 10 mg mazdutide vial?+
There is no single right amount. More water makes each draw bigger and easier to measure; less water makes it smaller. For example, 2 mL in a 10 mg vial gives 5 mg/mL, so 4 mg is 0.8 mL, or 80 units on a U-100 insulin syringe. That amount is only an example for the math, not a recommendation. The free Dose Track reconstitution calculator works it out for any vial and amount.
How many units is 4 mg of mazdutide?+
It depends on the concentration in your vial. At 5 mg/mL (10 mg mixed with 2 mL), 4 mg is 0.8 mL, which is 80 units on a U-100 insulin syringe, where 1 mL is 100 units. Divide the amount by the concentration to get mL, then multiply by 100.
What is the half-life of mazdutide?+
We could not open a primary human pharmacokinetic paper for mazdutide, so we do not list a half-life or time to peak here.
Can I track mazdutide in Dose Track?+
Yes, as a custom compound. Mazdutide is not in the built-in list, but you can add it yourself. You can then log each shot next to your other compounds, save your vial and how much water you added so every amount shows in syringe units, see how much is left in the vial, and get reminders. Your log stays on your phone.

Sources

  1. Ji L, et al. Once-weekly mazdutide in Chinese adults with obesity or overweight (GLORY-1). N Engl J Med. 2025.
  2. Gao L, et al. Treatment with 9-mg mazdutide for weight reduction in Chinese adults with obesity: the GLORY-2 randomized clinical trial. JAMA. 2026.
  3. Shirley M. Mazdutide: first approval. Drugs. 2025.

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