Short answer: The testosterone enanthate label lists androgen side effects without percentages. In men: breast enlargement, frequent or long erections and low sperm count at high doses. In all users: acne, extra hair, male-pattern baldness, fluid retention, nausea, liver test changes, polycythemia, raised cholesterol, headache, mood and libido changes, and injection-site pain. It has no boxed warning but warns about clots, blood pressure and abuse.
What Testosterone enanthate is approved for: In males, testosterone enanthate injection is approved as replacement for low or absent natural testosterone from primary hypogonadism or hypogonadotropic hypogonadism, and to stimulate puberty in carefully selected males with clearly delayed puberty. In women it may be used secondarily for advancing inoperable metastatic breast cancer one to five years after menopause. Safety and effectiveness in men with age-related hypogonadism have not been established (Indications and Usage).
Source
Testosterone enanthate injection, USP, prescribing information. Hikma. DailyMed, version published May 11, 2026. DailyMed setid e89d6458-428c-4256-97a3-f1fa851293c1
No. The current Testosterone enanthate label has no boxed warning.
These are the label's own numbers from the Adverse Reactions section. Where the label compares with placebo (a dummy treatment), both columns are shown, so you can see how much more often a reaction happened on Testosterone enanthate.
| Body system | Reactions the label lists |
|---|---|
| Endocrine and Urogenital, Female | Amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. |
| Male | Gynecomastia, and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages. |
| Skin and Appendages | Hirsutism, male pattern baldness, and acne. |
| Cardiovascular Disorders | Myocardial infarction, stroke. |
| Fluid and Electrolyte Disturbances | Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates. |
| Gastrointestinal | Nausea, cholestatic jaundice, alterations in liver function tests; rarely, hepatocellular neoplasms, peliosis hepatis. |
| Hematologic | Suppression of clotting factors II, V, VII, and X; bleeding in patients on concomitant anticoagulant therapy; polycythemia. |
| Nervous System | Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia. |
| Metabolic | Increased serum cholesterol. |
| Vascular Disorders | venous thromboembolism |
| Miscellaneous | Rarely, anaphylactoid reactions; inflammation and pain at injection site. |
The label gives no percentages and no placebo comparison. For women it says the most common effects are menstrual changes and virilization (deeper voice, clitoral enlargement), which usually do not reverse after stopping.
Hemoglobin and hematocrit should be checked periodically for polycythemia (too many red blood cells) in people on high doses of androgens.
Because androgens can change cholesterol, the label calls for repeated cholesterol tests and caution in people with a history of heart attack or coronary artery disease.
Bone age X-rays every six months are called for in boys treated before puberty, because androgens can close growth plates early.
The Warnings and Precautions part of the label lists these. Each line gives the label's heading and what it means in plain words.
High calcium. In people with breast cancer and people who are immobilized, androgens can raise blood calcium. If it happens, the drug is stopped.
Liver problems. Long use of high doses has been linked to peliosis hepatis and liver tumors, including liver cancer. If jaundice or abnormal liver tests appear, the androgen is stopped and the cause looked for.
Prostate in older men. Older men on androgens may have a higher risk of prostate enlargement and prostate cancer.
Blood clots. Deep vein thrombosis and pulmonary embolism have been reported with testosterone products. Leg pain, swelling, warmth or redness, or sudden shortness of breath are checked, and treatment is stopped if a clot is suspected.
Heart risk. Long-term heart outcome trials have not been done, and studies so far are inconclusive about heart attack, stroke and heart-related death.
Blood pressure. Testosterone can raise blood pressure. It is checked periodically, and testosterone is not recommended with uncontrolled high blood pressure.
Abuse. Testosterone has been abused at doses above those approved, often with other anabolic steroids, which can cause serious heart and mental health problems.
Fluid retention. Salt and water retention can cause swelling, with or without heart failure, in people with heart, kidney or liver disease.
Breast enlargement. Gynecomastia frequently develops and occasionally persists in men treated for hypogonadism.
Teen growth. In young people with delayed puberty, androgens can speed bone maturation without extra height, possibly reducing adult height; bone age is checked every six months.
Virilization in women. Women are watched for a deeper voice, extra hair, acne, clitoral enlargement and period changes; the label says stopping at the first mild signs is needed to prevent permanent changes.
From the Information for Patients (Precautions) that comes with Testosterone enanthate:
Dose Track has a side-effect log. Each entry records the symptom, a severity (none, mild, moderate, severe or life-threatening), the date and an optional note, and can be tied to a specific dose or logged on its own. The history screen shows what you logged over time, which makes it easier to tell your prescriber when a reaction started and whether it is easing. The app records what you enter; it does not judge whether a symptom is serious. For anything on the label's call-your-doctor list, call your doctor.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.