Short answer: Prometrium (progesterone): 77°F (25°C), excursions 59-86°F (15-30°C), protected from excessive moisture. Bijuva (estradiol and progesterone): 68-77°F (20-25°C), excursions 59-86°F, in a blister package of 30 that is not child-resistant. Neither label gives a fridge instruction. Prometrium contains peanut oil. Sources: each label, How Supplied or section 16, and the patient leaflets.
| Product | Label storage | Patient leaflet | Packaging |
|---|---|---|---|
| Prometrium 100 mg and 200 mg capsules | 25°C (77°F); excursions 15-30°C (59-86°F). Protect from excessive moisture. | Same temperature; protect from excessive moisture | Bottles of 30; dispensed in a tight, light-resistant container |
| Bijuva 0.5 mg/100 mg and 1 mg/100 mg capsules | 20-25°C (68-77°F); excursions 15-30°C (59-86°F) | Room temperature 68-77°F (20-25°C) | Blister package of 30; not child-resistant |
Prometrium How Supplied also tells the pharmacy: “Dispense in tight, light-resistant container as defined in USP/NF, accompanied by a Patient Insert.” Keeping the capsules in that container keeps them dry and out of the light.
Yes. Both strengths list peanut oil NF as an inactive ingredient, and the label says Prometrium “contain[s] peanut oil and is contraindicated in patients allergic to peanuts.” The patient leaflet repeats this in capitals. This is about the ingredient, not storage, but it is printed right beside the storage text. See Prometrium side effects.
Prometrium is taken at bedtime and Bijuva each evening with food, per their labels; the schedules are on the Prometrium and Bijuva pages, with missed-dose rules for Prometrium and Bijuva. Comparisons: Bijuva vs Prometrium and Prometrium vs Crinone.
No ice pack is needed. Keep the bottle or blister pack in your carry-on, within 59-86°F (15-30°C), out of a hot car and, for Prometrium, away from damp places like a steamy bathroom.