Short answer: Skip it. The Addyi label says that if a bedtime dose is missed, take the next dose at bedtime the next day, and do not double the next dose. Addyi is only taken at bedtime because taking it while awake raises the risk of low blood pressure, fainting, injury and sleepiness.
| Situation | What the label says |
|---|---|
| Schedule | 100 mg once daily at bedtime (2.1) |
| Missed a bedtime dose | Take the next dose at bedtime the next day (2.2) |
| Doubling up | Do not double the next dose (2.2) |
| Daytime dosing | Not allowed; higher risk of low blood pressure and fainting (2.1) |
| Alcohol | Wait 2 hours after 1 or 2 drinks; skip after 3 or more (5.1) |
Section 2.2 says that if a dose of Addyi is missed at bedtime, take the next dose at bedtime on the next day, and do not double the next dose.
Example: you forgot your Addyi last night and remember at breakfast. Under the label you would not take it in the morning; you would take your usual tablet at bedtime tonight.
Section 2.1 says Addyi is dosed at bedtime because taking it while awake increases the risk of low blood pressure, fainting, accidental injury and sleepiness. Flibanserin has a half-life of about 11 hours (section 12.3).
The boxed warning and section 5.1 say to wait at least two hours after one or two standard drinks before taking Addyi at bedtime, and to skip that night's dose after three or more drinks. A skipped dose for this reason follows the same rule: take the next one at bedtime the following day.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.