Short answer: The Trulicity label starts adults at 0.75 mg once a week. After 4 weeks the dose may go to 1.5 mg, and if more blood sugar control is needed it goes up in 1.5 mg steps after at least 4 weeks at each dose, to a maximum of 4.5 mg weekly. Children 10 and older start at 0.75 mg with a maximum of 1.5 mg.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Trulicity is approved for: Trulicity is approved, along with diet and exercise, to improve blood sugar control in adults and children 10 years and older with type 2 diabetes, and to lower the risk of major heart and blood vessel events in adults with type 2 diabetes who have heart disease or several heart risk factors (section 1).
Source
TRULICITY (dulaglutide) injection, prescribing information and Medication Guide. Eli Lilly. DailyMed, version published August 10, 2026. DailyMed setid 463050bd-2b1c-40f5-b3c3-0a04bb433309
Trulicity is injected under the skin once a week, at any time of day, with or without food, in the stomach area, thigh or upper arm. The label says to rotate injection sites with each dose (section 2.4).
With insulin, Trulicity and insulin are given as separate injections and never mixed; they can be in the same body area but not right next to each other (section 2.4).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Who | Start | Next step | Further steps | Maximum |
|---|---|---|---|---|
| Adults | 0.75 mg once weekly | 1.5 mg once weekly after 4 weeks, for additional glycemic control | 1.5 mg increments after at least 4 weeks on the current dose (3 mg, then 4.5 mg) | 4.5 mg once weekly |
| Children 10 years and older | 0.75 mg once weekly | 1.5 mg once weekly after at least 4 weeks on 0.75 mg, if needed | None | 1.5 mg once weekly |
The label says to follow the step-up schedule to reduce the risk of stomach and gut side effects.
Increases beyond 1.5 mg are in 1.5 mg steps, after at least 4 weeks on the current dose, and only if more glycemic control is needed.
The weekly day can be changed if the last dose was given 3 or more days before the new day.
With insulin or a sulfonylurea, the label says lowering the dose of those medicines may reduce the risk of low blood sugar.
If a dose is missed, take it as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days remain, skip it and take the next dose on the regular day. Either way, the regular once-weekly schedule then continues.
More on this: missed a dose of Trulicity.
In Dose Track you set up Trulicity as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.