VIP Reconstitution Calculator, Units & Half-Life
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[Peptide · Compound guide]

VIP (Vasoactive Intestinal Peptide): reconstitution, units and half-life

Vial sizes · Worked example · Units chart · Half-life notes

What is VIP?

Vasoactive intestinal peptide (VIP) is a 28-amino-acid neuropeptide found in the gut, lungs and brain. A synthetic version, aviptadil, has been tested in clinical trials. VIP is not FDA approved for any use.

Also known as: Vasoactive intestinal peptide, Aviptadil.

Common vial sizes

Powder vials are usually labeled 5 mg.

Water and syringe-unit charts by vial size: 5 mg

Worked reconstitution example

Here is the math for a 5 mg vial mixed with 2 mL of bacteriostatic water, drawing 50 mcg with a U-100 insulin syringe (1 mL = 100 units).

  1. Concentration. 5 mg ÷ 2 mL = 2.5 mg/mL
  2. Volume to draw. 50 mcg ÷ 2.5 mg/mL = 0.02 mL
  3. Syringe units. 0.02 mL × 100 = 2 units
The amount here is an example to show the math, not a recommendation. How much to take is a decision for you and your prescriber.

Units chart at 2.5 mg/mL

5 mg vial + 2 mL water. Amounts are examples for the conversion, not doses.
AmountVolumeU-100 syringe
25 mcg0.01 mL1 units
50 mcg0.02 mL2 units
100 mcg0.04 mL4 units

For any other vial size or amount, the free peptide reconstitution calculator works backwards from the amount you want and suggests a water volume that lands on a clean syringe mark.

What do human trials show?

In an open phase 2 study (Prasse 2010), 20 people with active sarcoidosis inhaled nebulized VIP for 4 weeks. It was well tolerated and lowered an inflammatory signal (TNF-alpha) in lung fluid; there was no placebo group.

In the TESICO trial (Lancet Respir Med 2023), intravenous aviptadil was tested against placebo in hospitalized adults with COVID-19 respiratory failure. Evidence for VIP injected under the skin or used as a nasal spray outside trials is limited.

VIP half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not open a primary human source with a half-life for VIP by the routes people use outside hospitals, so we do not list one here.

How to track VIP in Dose Track

  1. Add VIP as a custom compound. It is not in the built-in list, but a custom compound gets the same vial, units and reminder tools, and it sits next to everything else you take.
  2. Save your vial: enter the vial size and how much water you added. From then on every amount you log shows as syringe units, and the reconstitution planner suggests a water volume that lands on a clean mark.
  3. Log each shot. The app subtracts it from the vial, shows what is left, and warns you before you run out.
  4. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  5. Your log stays on your phone.
Thymosin Alpha-1Thymalfasin, Zadaxin · half-life about 2 hours KPVLys-Pro-Val LL-37Cathelicidin

Frequently asked questions

How much bacteriostatic water do I add to a 5 mg VIP vial?+
There is no single right amount. More water makes each draw bigger and easier to measure; less water makes it smaller. For example, 2 mL in a 5 mg vial gives 2.5 mg/mL, so 50 mcg is 0.02 mL, or 2 units on a U-100 insulin syringe. That amount is only an example for the math, not a recommendation. The free Dose Track reconstitution calculator works it out for any vial and amount.
How many units is 50 mcg of VIP?+
It depends on the concentration in your vial. At 2.5 mg/mL (5 mg mixed with 2 mL), 50 mcg is 0.02 mL, which is 2 units on a U-100 insulin syringe, where 1 mL is 100 units. Divide the amount by the concentration to get mL, then multiply by 100.
What is the half-life of VIP?+
We could not open a primary human source with a half-life for VIP by the routes people use outside hospitals, so we do not list one here.
Can I track VIP in Dose Track?+
Yes, as a custom compound. VIP is not in the built-in list, but you can add it yourself. You can then log each shot next to your other compounds, save your vial and how much water you added so every amount shows in syringe units, see how much is left in the vial, and get reminders. Your log stays on your phone.

Sources

  1. Prasse A, et al. Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis. Am J Respir Crit Care Med. 2010.
  2. Brown SM, et al. Intravenous aviptadil and remdesivir for COVID-19-associated hypoxaemic respiratory failure (TESICO): a randomised, placebo-controlled trial. Lancet Respir Med. 2023.

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