How to Store Synjardy, Xigduo XR and Invokamet
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[Storage · Synjardy, Xigduo XR and Invokamet]

How to store Synjardy, Xigduo XR and Invokamet

Quoted from the US label · Unopened vs in use · Travel · Sources · Reviewed

Short answer: All three labels say store at 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C). Invokamet and Invokamet XR add: store in the original container to protect from moisture, and a pill box or pill organizer is allowed for up to 30 days. Synjardy and Xigduo XR give only the temperature. None gives a fridge instruction. Sources: section 16 and the Medication Guides.

What do the three labels say?

Synjardy and Synjardy XR (empagliflozin with metformin), Xigduo XR (dapagliflozin with metformin) and Invokamet and Invokamet XR (canagliflozin with metformin) combine an SGLT2 inhibitor with metformin in one tablet.

Synjardy, Xigduo XR and Invokamet US prescribing information, section 16, and Medication Guides.
ProductSection 16Medication Guide
Synjardy and Synjardy XR20-25°C (68-77°F); excursions 15-30°C (59-86°F)Room temperature 68-77°F (20-25°C)
Xigduo XR20-25°C (68-77°F); excursions 15-30°C (59-86°F)Room temperature 68-77°F (20-25°C)
Invokamet and Invokamet XR20-25°C (68-77°F); excursions 15-30°C (59-86°F). Store and dispense in the original container. Pill box or pill organizer allowed for up to 30 days.68-77°F (20-25°C). Original container to protect from moisture. Pill box or pill organizer allowed for up to 30 days.

Can Invokamet go in a pill organizer?

Yes, for a limited time. Invokamet section 16: “Store and dispense in the original container. Storage in a pill box or pill organizer is allowed for up to 30 days.” Section 17 tells prescribers to advise patients to keep it “in the original bottle to protect from moisture.” The bottle labels repeat: “May be stored in a pill box for up to 30 days.”

The Synjardy and Xigduo XR labels do not mention pill organizers either way. Plain Invokana is on the SGLT2 tablets page.

Dosing and comparisons

Dosing: Synjardy, Xigduo XR and Invokamet. Missed a dose: Synjardy, Xigduo XR, Invokamet. Comparisons: Jardiance vs Synjardy, Farxiga vs Xigduo XR, Invokana vs Invokamet and Janumet vs Synjardy.

How do you travel with them?

No ice pack is needed. Keep tablets in the closed bottle in your carry-on, within 59-86°F (15-30°C), and out of a hot car. For Invokamet, a pill organizer is fine for a trip of up to 30 days, per the label.

Quoted from the current US label on DailyMed, not personalized advice. Labels change; the leaflet in your own carton, your pharmacist and your prescriber are the final word on how to store it.
Jardiance, Farxiga, Invokana, SteglatroRoom temperature SGLT2 tablets; Steglatro kept dry. Metformin, Januvia, Janumet, TradjentaRoom temperature tablets; metformin in a light-resistant container. Rybelsus and Ozempic tabletsRoom temperature, in the original bottle, away from moisture.

Frequently asked questions

Can I put Invokamet in a weekly pill box?+
Yes. The label says storage in a pill box or pill organizer is allowed for up to 30 days. Otherwise keep it in the original container to protect from moisture.
How should Synjardy be stored?+
At 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C). The label gives no fridge instruction.
Does Xigduo XR need refrigeration?+
The label gives no fridge instruction. It says store at 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C).

Sources

  1. Synjardy and Synjardy XR (empagliflozin and metformin HCl) tablets US prescribing information and Medication Guide, DailyMed, version of August 27, 2026
  2. Xigduo XR (dapagliflozin and metformin HCl extended-release) tablets US prescribing information and Medication Guide, DailyMed, version of August 26, 2026
  3. Invokamet and Invokamet XR (canagliflozin and metformin HCl) tablets US prescribing information and Medication Guide, DailyMed, version of August 25, 2026

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