Short answer: For adults, the Tresiba label says to inject your daily dose during waking hours when you notice you missed it, and to make sure at least 8 hours pass between two Tresiba injections. For children, the label says to call the healthcare provider and check blood sugar more often until the next scheduled dose.
| Situation | What the label says |
|---|---|
| Schedule (adults) | Once daily, any time of day (2.2) |
| Adult missed a dose | Inject during waking hours once you notice (2.2) |
| Minimum time between doses | At least 8 hours (2.2) |
| Child missed a dose | Call the healthcare provider; check blood sugar more often (2.2) |
| Half-life | About 25 hours at steady state (12.3) |
Section 2.2 says adults who miss a dose should inject their daily dose during waking hours when they discover the missed dose, and make sure at least 8 hours have passed between two Tresiba injections. The Patient Information says the same: make sure there are at least 8 hours between your doses.
Example: you normally inject at 9 p.m. and notice at 10 a.m. the next day that you skipped last night. That is 13 hours after your usual time and more than 8 hours since your previous dose, so under the label you would inject at 10 a.m. Your next injection then needs to be at least 8 hours later, so 6 p.m. or after, not 9 a.m. the next morning by habit.
The rule is different. Section 2.2 says that for children, the family should contact the healthcare provider for guidance and check blood sugar more often until the next scheduled dose. There is no "inject when you notice" rule for children.
Tresiba is long-acting, with a half-life of about 25 hours at steady state (section 12.3), and the adult label allows dosing at any time of day. That is why the label allows a late dose as long as two doses are 8 or more hours apart.
The label says dose changes may be needed when meals, activity or illness change, to lower the risk of low or high blood sugar (section 2.2). After a missed or shifted dose, checking more often is a reasonable thing to raise with your diabetes team.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.