Short answer: The Imcivree label says that if a dose is missed, resume the once-daily schedule with the next scheduled dose. The Patient Information puts it plainly: inject your next dose at the regularly scheduled time the next day. There is no catch-up dose, and the label does not allow two doses in one day.
| Situation | What the label says |
|---|---|
| Schedule | Once daily, when you first wake up, with or without food (Patient Information) |
| Missed a dose | Resume with the next scheduled dose (2.5) |
| Catch-up | None; inject at the usual time the next day (Patient Information) |
| Injection sites | Abdomen, thigh or arm, a different site each day (2.5) |
| Half-life | About 11 hours (12.3) |
Section 2.5 says that if a dose is missed, resume the once-daily regimen as prescribed with the next scheduled dose. The Patient Information says to inject the next dose at the regularly scheduled time the next day.
Example: you inject Imcivree when you wake up at 7 a.m. and realize in the evening that you forgot. Under the label you would not inject that evening; you would take your usual dose at 7 a.m. the next day.
Setmelanotide has an effective half-life of about 11 hours (section 12.3). The label's dosing starts low and increases every 2 weeks if tolerated (section 2.2), so ask your prescriber before restarting after a longer gap.
Imcivree comes in a multiple-dose vial. The label's storage section limits how long a vial can be kept once out of the refrigerator (up to 30 days at the allowed temperatures). A skipped day leaves more in the vial, but it does not extend that limit.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.