Prolactin Test: What It Is and Why Timing Matters
[Glossary · How doses act in the body]

Prolactin

Also called PRL, prolactin test, serum prolactin · Reviewed

Definition: Prolactin is a hormone made by the pituitary gland. Its main job is to make breast tissue grow in pregnancy and make milk after birth. MedlinePlus says levels are normally low in men and in women who are not pregnant or breastfeeding. A prolactin test measures it in a blood sample.

Why it shows up on labs

MedlinePlus says high prolactin can affect how the testicles work and cause a lower sex drive and erectile dysfunction in men. In women, it can cause period problems and infertility. So prolactin is one of the tests used to look for the cause of low sex drive, erectile dysfunction or infertility.

The most common cause of high prolactin, according to MedlinePlus, is a prolactinoma, a benign tumor of the pituitary gland. Certain medicines, an underactive thyroid and kidney disease can also raise it. The test cannot show the cause by itself.

The testosterone labels we checked (Depo-Testosterone and Xyosted) do not list prolactin as a routine lab. MedlinePlus lists it among the tests used to find the cause of low sex drive or erectile dysfunction in men.

Common mix-ups

  • Time of day matters. Prolactin changes through the day. MedlinePlus says the draw is usually scheduled for three to four hours after you wake up.
  • Small rises have everyday causes. MedlinePlus lists stress, exercise, sex, high-protein diets and certain medicines. Your provider may repeat the test to see if it stays high.
  • Fasting. You may be asked not to eat or drink for several hours first.

Each lab sets its own reference range, so read your result against the range printed on your own report, and talk with your clinician about what it means for you.

Read more on Dose Track: Libido · Logging lab results in Dose Track

General education drawn from labels and published studies, not personal medical advice. Your prescriber, pharmacist and the label that came with your product are the final word.

Frequently asked questions

Why is a prolactin test done in the morning?+
Prolactin changes through the day. MedlinePlus says the blood draw is usually scheduled for three to four hours after you wake up.
Can stress or exercise raise prolactin?+
MedlinePlus says small increases can come from stress, exercise and even sex, which is why a high result may be retested.