Short answer: Both contain ertugliflozin, an SGLT2 inhibitor.12 Steglatro is ertugliflozin alone, once each morning. Segluromet adds metformin and is taken twice daily with meals, so it carries a boxed warning for lactic acidosis. Both are not recommended with an eGFR below 45 and are held 4 days before surgery with long fasting. Neither label reports a trial of one against the other.
| Steglatro | Segluromet | |
|---|---|---|
| What is in it | Ertugliflozin 5 or 15 mg1 | Ertugliflozin 2.5 or 7.5 mg with metformin 500 or 1,000 mg per tablet2 |
| How taken | Once daily in the morning, with or without food1 | Twice daily with meals2 |
| Maximum daily dose | Ertugliflozin 15 mg1 | Ertugliflozin 15 mg and metformin 2,000 mg2 |
| Kidney limits | Not recommended with an eGFR below 451 | Not recommended with an eGFR below 45; not used below 30 or on dialysis2 |
| Before surgery | Held at least 4 days, if possible1 | Held at least 4 days, if possible2 |
| Female genital yeast infection, pooled trials | 9.1% and 12.2% vs 3.0% on placebo1 | Same pooled table: 9.1% and 12.2% vs 3.0%2 |
| Missed dose | Take as soon as possible; do not double1 | Take as soon as possible; do not double2 |
| Boxed warning | None1 | WARNING: LACTIC ACIDOSIS2 |
Both labels list ketoacidosis even with blood sugar below 250 mg/dL, lower limb amputation, fluid loss, urinary and genital infections including Fournier's gangrene, and low blood sugar with insulin or a sulfonylurea.12 Segluromet adds the metformin warnings: lactic acidosis, stopping around some contrast scans, and lower vitamin B12, with blood counts checked yearly and B12 every 2 to 3 years. Added to metformin, low blood sugar was 7.2% and 7.8% on ertugliflozin vs 4.3% on placebo.2
Which, if either, fits is for your prescriber. More detail: Steglatro side effects, Segluromet side effects, the Steglatro and Segluromet dosing schedules, the Steglatro missed-dose page and Steglatro vs Jardiance: how do the two SGLT2 tablets differ?.