Short answer: The Menopur label says that if a dose is missed or forgotten, the next dose should not be doubled, and you should call your healthcare provider for further dosing instructions. The Patient Information says to call right away. There is no catch-up rule, because each dose is set by your clinic from ultrasound and blood tests.
| Situation | What the label says |
|---|---|
| Schedule | Daily under the skin from cycle day 2 or 3 (2.2) |
| Missed a dose | Call your healthcare provider right away (Patient Information; 17.3) |
| Doubling up | Do not double the next dose (17.3) |
| Starting dose | 225 International Units a day (2.2) |
| Most per day | 450 International Units (2.2) |
Section 17.3 tells prescribers to inform women that if a dose of Menopur is missed or forgotten, the next dose should not be doubled and she should call her healthcare provider for further dosing instructions. The Patient Information says: if you miss a dose of Menopur, call your healthcare provider right away. Do not double the amount of Menopur you are using.
Section 2.2 says dosing is individualized. Treatment starts at 225 International Units a day, is adjusted after 5 days based on ultrasound and blood estradiol levels, and is not adjusted more often than every 2 days or by more than 150 International Units at a time. Daily doses above 450 International Units are not given, and treatment should not exceed 20 days. A missed day changes that picture, so the clinic sets the next step.
No. Section 16.2 says use Menopur immediately after mixing and throw away unused material.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.