Estradiol valerate is estradiol, the main human estrogen, attached to a valerate ester and dissolved in oil for injection into muscle. It is sold as Delestrogen and as generic injection.
Also known as: Delestrogen.
Delestrogen comes in 5 mL multi-dose vials at 10 mg/mL (in sesame oil), 20 mg/mL and 40 mg/mL (in castor oil). It is already a solution, so there is nothing to mix.
Estradiol valerate is already a solution, so there is no mixing. The only math is turning an amount in mg into a volume. Here it is at 20 mg/mL for 10 mg.
10 mg ÷ 20 mg/mL = 0.5 mL0.5 mL × 100 = 50 units| Amount | Volume | U-100 syringe |
|---|---|---|
| 5 mg | 0.25 mL | 25 units |
| 10 mg | 0.5 mL | 50 units |
| 15 mg | 0.75 mL | 75 units |
| 20 mg | 1 mL | 100 units |
The FDA Delestrogen label approves estradiol valerate for moderate to severe hot flashes and vaginal atrophy of menopause, for low estrogen due to hypogonadism, castration or primary ovarian failure, and for palliation of advanced androgen-dependent prostate cancer. For the menopause and low-estrogen uses, the usual dose is 10 to 20 mg every four weeks; for prostate cancer, 30 mg or more every one or two weeks. It is injected deep into the upper outer buttock muscle, using a dry needle and syringe.
The label carries boxed warnings that estrogens increase the risk of endometrial cancer, and about cardiovascular and other risks from the Women's Health Initiative studies (heart attack, stroke, breast cancer, blood clots and probable dementia in older women). It says women with a uterus should also get a progestin, to use the lowest effective dose and reassess every 3 to 6 months, and that estradiol is broken down by CYP3A4, so St John's wort and rifampin can lower levels while grapefruit juice can raise them.
The FDA Delestrogen label gives no half-life; it says a single injection into muscle is absorbed over several weeks. In a small study of 5 mg injected into muscle in arachis oil (Oriowo 1980), estradiol peaked about 2 days after the shot and stayed raised for 7 to 8 days; Dose Track uses 2 days (48 hours) for time to peak. The app's 4-day half-life is a modeling value we could not confirm, so it is not listed.
Numbers shown are the values Dose Track uses, listed only where they agree with the source above. Half-life varies from person to person and with injection site.