How to Store Delestrogen (Estradiol Valerate)
[Storage · Delestrogen]

How to store Delestrogen (estradiol valerate injection)

Quoted from the US label · Unopened vs in use · Travel · Sources · Reviewed

Short answer: Store Delestrogen vials at room temperature, 68-77°F (20-25°C). The label says cold storage may cause some crystals to separate out, which redissolve readily on warming. It also says to use a dry needle and syringe, since a wet one may make the solution cloudy. No fridge is needed. Source: Delestrogen label, Storage and Dosage and Administration.

What does the Delestrogen label say?

Storage: “Store between 20° to 25°C (68° to 77°F).” The Patient Information says the same. Delestrogen comes in 5 mL multiple dose vials of 10, 20 and 40 mg/mL (How Supplied).

Delestrogen US label, How Supplied, Storage, and Dosage and Administration.
QuestionLabel answer
Temperature68-77°F (20-25°C)
Vials5 mL multiple dose vials, 10, 20 or 40 mg/mL
Cold storageMay cause crystals to separate; they redissolve readily on warming
Before useInspect; the solution is clear, colorless to yellow
Needle and syringeUse a dry needle and syringe
Time limit after first useNot stated in the label

What if Delestrogen has crystals or looks cloudy?

Crystals: Dosage and Administration says storage at low temperatures may result in the separation of some crystalline material which redissolves readily on warming.

Cloudy: the label says a wet needle or syringe may cause the solution to become cloudy, but that this does not affect the potency of the material. It also says to inspect the vial for particles and color before each use.

How long does an opened Delestrogen vial last?

The label does not give a time limit for a vial after the first dose is drawn, beyond the expiration date. The 10 mg/mL strength is in sesame oil with chlorobutanol, and the 20 and 40 mg/mL strengths are in castor oil with benzyl benzoate and benzyl alcohol. Ask your pharmacist if you are unsure about a vial.

See the Delestrogen dosing schedule, Delestrogen side effects and the estradiol valerate page.

How do you travel with it?

Delestrogen is stored at room temperature, 68-77°F (20-25°C). Cold can make crystals form, so keeping it away from ice packs avoids that.

  • TSA allows medically necessary liquids over 3.4 oz in carry-on bags; declare them at the checkpoint for inspection.
  • Unused syringes and pen needles are allowed when they travel with the injectable medicine.
  • Ice packs and gel packs that keep medicine cool may go through frozen, partly frozen or melted.
  • Keep medicine in your carry-on, not checked luggage, where you cannot control the temperature. Do not let it touch an ice pack directly, since most labels say do not freeze.

More in the travel guide.

Quoted from the current US label on DailyMed, not personalized advice. Labels change; the leaflet in your own carton, your pharmacist and your prescriber are the final word on how to store it.

Frequently asked questions

Does Delestrogen need to be refrigerated?+
No. The label says store between 68°F and 77°F (20-25°C).
Why does my Delestrogen have crystals?+
The label says storage at low temperatures may make some crystalline material separate, which redissolves readily on warming.
Why did my Delestrogen turn cloudy?+
The label says a wet needle or syringe may make the solution cloudy, and that this does not affect potency. It says to use a dry needle and syringe.