Short answer: Kyzatrex is testosterone undecanoate capsules taken with food, starting at 200 mg twice daily.1 Depo-Testosterone is testosterone cypionate injected deep into the buttock muscle, 50 to 400 mg every two to four weeks.2 Kyzatrex doses step by blood tests 3 to 5 hours after the morning dose; Depo-Testosterone doses go by response and side effects. Neither has a boxed warning, and neither label compares the two.
| Kyzatrex | Depo-Testosterone | |
|---|---|---|
| How taken | Capsules by mouth, morning and evening, with food1 | Injected deep into the buttock muscle; never into a vein2 |
| Dose | 200 mg twice daily to start; 100 mg once daily to 400 mg twice daily1 | 50 to 400 mg every two to four weeks2 |
| How the dose is adjusted | Blood test 3 to 5 hours after the morning dose, 7 days after a start or change; aim 460 to 971 ng/dL1 | By response and side effects; no target level given2 |
| Side effect data | Hypertension 2.6% in a 6-month study; average systolic rise 1.8 mm Hg at 6 months1 | Listed without percentages, including acne, breast enlargement, fluid retention and injection site pain2 |
| Other approved use | None1 | Starting puberty in hypogonadal boys2 |
| Missed dose | No rule in the label1 | No rule in the label2 |
| Boxed warning | None1 | None2 |
Both list the testosterone set: blood clots, higher blood pressure, prostate effects, fluid retention, breast enlargement and abuse.12 Kyzatrex checks hematocrit before starting and about every 3 months, and is not swapped with other oral testosterone undecanoate products.1 The Depo-Testosterone label checks hemoglobin and hematocrit periodically, says it is not interchangeable with testosterone propionate, and flags its benzyl alcohol preservative.2
Which, if either, fits is for your prescriber. More detail: Kyzatrex side effects, Depo-Testosterone side effects, the Kyzatrex and Depo-Testosterone dosing schedules, the Kyzatrex and Depo-Testosterone missed-dose pages, the testosterone undecanoate and testosterone cypionate guides, and Jatenzo vs Kyzatrex vs Tlando: how do the oral testosterone capsules differ?.