Short answer: Keep unopened Tresiba in the fridge at 36-46°F (2-8°C) until the expiration date, or at room temperature up to 86°F (30°C) for 56 days (8 weeks). Once in use, FlexTouch pens and vials last 56 days in the fridge or at room temperature up to 86°F. Never freeze it. Source: Tresiba label, section 16.2, Table 18.
Section 16.2: “Store unused TRESIBA in a refrigerator (36ºF to 46ºF [2ºC to 8ºC]). Do not store in the freezer or directly adjacent to the refrigerator cooling element. Do not freeze. Do not use TRESIBA if it has been frozen.” Vials are kept in the original carton to protect them from light.
| Form | Unopened, refrigerated | Unopened, room temp (up to 86°F) | In use (fridge or room temp up to 86°F) |
|---|---|---|---|
| U-100 FlexTouch pen, 3 mL | Until expiration date | 56 days (8 weeks) | 56 days (8 weeks) |
| U-100 vial, 10 mL | Until expiration date | 56 days (8 weeks) | 56 days (8 weeks) |
| U-200 FlexTouch pen, 3 mL | Until expiration date | 56 days (8 weeks) | 56 days (8 weeks) |
Fifty-six days, and unlike some insulin pens it may go back in the fridge. Patient Information: store the pen you are currently using “in the refrigerator between 36°F to 46°F (2°C to 8°C) or keep at room temperature up to 86°F (30°C).” The pen “should be thrown away after 56 days if it is refrigerated or kept at room temperature, even if it still has insulin left in it and the expiration date has not passed.”
The vial Patient Information says the same for vials, and adds that unopened vials kept at room temperature are thrown away after 56 days. Keep Tresiba away from direct heat and light. For a missed dose, see missed a Tresiba dose.
Frozen: do not use it (section 16.2). Warm: room-temperature storage stops at 86°F (30°C), and the label gives no allowance above that. Ask your pharmacist about insulin that went outside these limits. See also left out of the fridge.
Tresiba in use can travel at room temperature up to 86°F (30°C) for the rest of its 56 days. Unopened spares can also be kept up to 86°F, but that starts their own 56-day limit.
More in the travel guide.