Short answer: Unopened Reclast bottles are stored at 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C). After opening, the solution is stable for 24 hours at 36-46°F (2-8°C), and refrigerated solution must reach room temperature before the infusion. Reclast is given in a clinic, so the clinic handles storage. Source: Reclast label, sections 2.9 and 16.
Reclast (zoledronic acid) is a once-yearly intravenous infusion for osteoporosis (once every 2 years for prevention of postmenopausal osteoporosis) and a single infusion for Paget’s disease of bone. It comes as one 100 mL bottle holding 5 mg, ready to infuse.
| Stage | Label instruction |
|---|---|
| Unopened bottle | 20-25°C (68-77°F); excursions 15-30°C (59-86°F) |
| After opening | Stable for 24 hours at 2-8°C (36-46°F) |
| Before the infusion | If refrigerated, allow the solution to reach room temperature |
| Mixing | Must not contact calcium or other divalent cation-containing solutions; give through a separate vented infusion line |
| Infusion time | Not less than 15 minutes, then a 10 mL saline flush |
The Reclast Medication Guide has no storage section, since patients do not keep the bottle at home.
Section 16: “After opening the solution, it is stable for 24 hours at 2°C to 8°C (36°F to 46°F). If refrigerated, allow the refrigerated solution to reach room temperature before administration.” The label does not give a room-temperature time limit for an opened bottle.
Nothing to store at home. The label stresses getting a kidney function test (creatinine) before each dose, an oral exam by the prescriber before starting, and calcium and vitamin D as directed. Because it is once a year, the date is the thing to track. See the Reclast dosing schedule, missed a Reclast dose, Reclast side effects, Reclast vs Fosamax and Reclast vs Prolia.