Short answer: Keep Prolia in the fridge at 36-46°F (2-8°C) in its carton, away from light, and never frozen. Once out of the fridge it must stay at or below 77°F (25°C) and be used within 30 days, or be thrown away. Do not shake it. Prolia is given by a healthcare provider, so home storage only applies if you pick it up from a pharmacy. Source: Prolia label, section 16.
Section 16: “Store Prolia refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze.” Once removed from the refrigerator, Prolia “must not be exposed to temperatures above 25°C (77°F) and must be used within 30 days. Discard Prolia if not used within the 30 days.” It also says protect from direct light and heat, and avoid vigorous shaking.
| Question | Label answer |
|---|---|
| Temperature | Refrigerator, 36-46°F (2-8°C), in the original carton |
| Freezer | Do not freeze |
| Out of the fridge | No higher than 77°F (25°C); use within 30 days or discard |
| Shaking | Avoid vigorous shaking |
| Before the injection | May stand in the carton to reach room temperature, usually 15 to 30 minutes; do not warm any other way (2.4) |
Section 2.3 says Prolia should be given by a healthcare provider, 60 mg under the skin once every 6 months. The Medication Guide has a section for patients who pick it up from a pharmacy: keep it in the refrigerator in the carton, do not freeze it, and once it is out of the refrigerator keep it at room temperature, up to 77°F (25°C), and use it within 30 days. It adds that warm temperatures will affect how Prolia works.
See the Prolia dosing schedule, Prolia side effects, missed a Prolia dose and Prolia vs Evenity.
If you carry Prolia from the pharmacy to the clinic, the label limit is 77°F (25°C) and 30 days once it is out of the fridge. An insulated bag helps in warm weather; keep it from touching an ice pack, since it must not freeze.
More in the travel guide.