Short answer: The Prolia label dose is 60 mg injected under the skin once every 6 months by a healthcare provider, in the upper arm, upper thigh or abdomen. Everyone takes calcium 1000 mg and at least 400 IU of vitamin D daily. If a dose is missed, it is given as soon as the patient is available, and later injections are every 6 months from that date.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Prolia is approved for: Prolia is a RANK ligand inhibitor approved for postmenopausal women with osteoporosis at high risk for fracture; to increase bone mass in men with osteoporosis at high risk for fracture; for steroid (glucocorticoid)-induced osteoporosis at high risk for fracture; and to increase bone mass in men on androgen deprivation therapy for nonmetastatic prostate cancer and women on adjuvant aromatase inhibitor therapy for breast cancer who are at high risk for fracture (section 1).
Source
PROLIA (denosumab) injection, for subcutaneous use, prescribing information and Medication Guide. Amgen. DailyMed, version published July 7, 2026. DailyMed setid 49e5afe9-a0c7-40c4-af9f-f287a80c5c88
Prolia is a 60 mg/mL single-dose prefilled syringe given by a healthcare provider as one injection under the skin of the upper arm, upper thigh or abdomen, once every 6 months (sections 2.3 and 3).
Before the first dose, pregnancy is ruled out in females who can become pregnant, low calcium is corrected, and people with advanced kidney disease are checked for CKD-MBD (sections 2.1, 2.2, 4).
The syringe may be left out of the refrigerator in its carton for 15 to 30 minutes to reach room temperature, and is not warmed any other way (section 2.4).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Item | What the label says |
|---|---|
| Dose | 60 mg as a single subcutaneous injection once every 6 months |
| Who gives it | A healthcare provider |
| Injection site | Upper arm, upper thigh, or abdomen |
| Calcium and vitamin D | Calcium 1000 mg daily and at least 400 IU vitamin D daily for all patients |
| Missed dose | Administer as soon as the patient is available; then every 6 months from the date of the last injection |
| Before starting | Rule out pregnancy; correct low calcium; in eGFR < 30 mL/min/1.73 m2, check iPTH, calcium, 25(OH) vitamin D and 1,25(OH)2 vitamin D |
In people prone to low calcium without advanced kidney disease, calcium, phosphorus and magnesium are checked 10 to 14 days after each injection. In advanced kidney disease, calcium is checked weekly for the first month and monthly after that.
An oral exam comes before starting, and a dental exam with preventive dentistry is recommended for people with jaw osteonecrosis risk factors.
If Prolia is stopped, the label says patients should be moved to another antiresorptive medicine because fracture risk rises after stopping.
Females who can become pregnant use effective birth control during treatment and for at least 5 months after the last dose.
No dose change is needed for kidney function, but people with creatinine clearance under 30 mL/min or on dialysis are at greater risk of severe low calcium.
If a dose of Prolia is missed, the injection is given as soon as the patient is available. After that, injections are scheduled every 6 months from the date of the last injection. The Medication Guide adds that skipping or delaying a dose raises the risk of broken bones, including in the spine.
More on this: missed a dose of Prolia.
Prolia is not given together with other denosumab products.
When Prolia is stopped, the label says to transition to an alternative antiresorptive therapy.
In Dose Track you set up Prolia as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.