Short answer: The generic glimepiride label used here says store at 20° to 25°C (68° to 77°F) and dispense in well-closed containers with safety closures; it states no excursion range and has no patient leaflet. Glucotrol XL says store at 68–77°F (20–25°C), excursions to 59°F and 86°F, protected from moisture and humidity, and its Patient Information adds a dry place, in its original container.
Glimepiride (generic Amaryl) and glipizide (Glucotrol XL is the extended-release brand) are sulfonylurea tablets. The brand Amaryl has no current label on DailyMed, so this page uses the current Aurobindo glimepiride tablets label; other makers carry their own.
| Question | Glimepiride tablets (Aurobindo) | Glucotrol XL |
|---|---|---|
| Section 16 temperature | 20° to 25°C (68° to 77°F) | 68–77°F (20–25°C) |
| Excursions | Not stated | Between 59°F and 86°F (15°C and 30°C) |
| Moisture | Not stated | Protected from moisture and humidity; Patient Information: a dry place |
| Light | Not stated | Not stated |
| Container | Dispense in well-closed containers with safety closures | Patient Information: in its original container |
| Patient leaflet | None in this label | Room temperature between 68°F to 77°F (20°C to 25°C) |
| Refrigerator | Not stated | Not stated |
Glimepiride section 16: “Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].” and “Dispense in well-closed containers with safety closures.”
Glucotrol XL section 16: “Recommended Storage: The tablets should be protected from moisture and humidity. Store at 68–77°F (20–25°C); excursions permitted between 59°F and 86°F (15°C and 30°C) [see USP Controlled Room Temperature].” The Patient Information says “Store GLUCOTROL XL at room temperature between 68°F to 77°F (20°C to 25°C)” and “Store GLUCOTROL XL in a dry place, in its original container.”
Duetact combines glimepiride with pioglitazone and has its own storage lines: see Actos, Oseni, Actoplus Met and Duetact.
Dosing: glimepiride and Glucotrol XL. Missed a dose: glimepiride. Side effects: glimepiride and Glucotrol XL. Comparison: glimepiride vs glipizide.
No ice pack is needed. Keep tablets in the labeled bottle in your carry-on and out of a hot car. For glimepiride, the label gives 68° to 77°F without an excursion range, so avoid long spells outside it. For Glucotrol XL, keep it dry and in its original container.