Short answer: The Prempro and Premphase Patient Information says to take a missed dose as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take 2 doses at the same time. Both are one tablet taken at the same time each day.
| Situation | What the label says |
|---|---|
| Schedule | One tablet at the same time each day (Patient Information) |
| Missed a dose | Take it as soon as possible (Patient Information) |
| Almost time for the next dose | Skip it; back to your normal schedule (Patient Information) |
| Doubling up | Do not take 2 doses at the same time (Patient Information) |
The prescribing information has no missed-dose instruction. The Patient Information, which is part of the same FDA label and covers both Prempro and Premphase, says: take one Prempro or Premphase tablet at the same time each day. If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take 2 doses at the same time.
Example: you take your tablet at breakfast and remember at lunch. Under the leaflet you would take it then. If you only remember the next morning, you would take that morning's tablet only.
The leaflet gives one rule for both products. Premphase comes in a pack with two kinds of tablets for different days of the cycle; the leaflet does not say what to do if the missed tablet was the last one of one kind. That is a question for your prescriber or pharmacist.
The Patient Information says estrogens should be used at the lowest dose possible, only as long as needed, and that you and your healthcare provider should talk regularly (for example, every 3 to 6 months) about the dose and whether you still need treatment.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.