Short answer: Section 2.5 of the Duavee label says to take a missed dose as soon as you remember, unless it is almost time for the next scheduled dose. Do not take two doses at the same time. The Patient Information adds: if you are not sure about your dosing, call your healthcare provider.
| Situation | What the label says |
|---|---|
| Schedule | One tablet daily (conjugated estrogens 0.45 mg / bazedoxifene 20 mg) (2.1) |
| Missed a dose | Take it as soon as remembered (2.5) |
| Almost time for the next dose | Skip it; take the next at the regular time (2.5, Patient Information) |
| Doubling up | Do not take two doses at the same time (2.5) |
| Half-life | About 30 hours for bazedoxifene; about 17 hours for total estrone (12.3) |
Section 2.5 says that if a dose of Duavee is missed, take it as soon as remembered unless it is almost time for the next scheduled dose, and do not take two doses at the same time.
The Patient Information says the same in plain words: if it is almost time for your next dose, skip the missed dose and take the next dose at your regular time. Do not take 2 doses at the same time unless your healthcare provider tells you to. If you are not sure about your dosing, call your healthcare provider.
The Patient Information says not to remove a tablet from the blister until you are ready to take it, and not to put Duavee in pill boxes or pill organizers. A dated log is one way to see whether today's tablet was taken without moving tablets out of the pack.
Section 12.3 gives a half-life of about 30 hours for bazedoxifene and about 17 hours for baseline-adjusted total estrone, which represents the conjugated estrogens.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.